Tachykinin Receptor 3 (TACR3)
[Edit]NK3R; NK3-R; TAC3RL; Neurokinin Beta Receptor; Neurokinin B receptor
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Tachykinin receptor 3, also known as TACR3, is a protein belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.
Huang et al. (1992) isolated cDNA clones encoding the human neurokinin-3 receptor from human brain mRNA. The cloned neurokinin-3 receptor was expressed in COS cells and Xenopus oocytes, where peptide binding affinity and intracellular effector activation were determined. Neurokinin B was the most potent agonist.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Tachykinin Receptor 3 (TACR3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Tachykinin Receptor 3 (TACR3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Tachykinin Receptor 3 (TACR3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Tachykinin Receptor 3 (TACR3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tachykinin Receptor 3 (TACR3) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA666Mu01 | Recombinant Tachykinin Receptor 3 (TACR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Tachykinin Receptor 3 (TACR3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Tachykinin Receptor 3 (TACR3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Tachykinin Receptor 3 (TACR3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tachykinin Receptor 3 (TACR3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Tachykinin Receptor 3 (TACR3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Tachykinin Receptor 3 (TACR3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Tachykinin Receptor 3 (TACR3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Tachykinin Receptor 3 (TACR3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tachykinin Receptor 3 (TACR3) | ELISA Kit Customized Service Offer |
- "cDNA sequence and heterologous expression of the human neurokinin-3 receptor."Biochem. Biophys. Res. Commun. 184:966-972(1992) [PubMed] [Europe PMC] [Abstract]
- "Molecular characterisation, expression and localisation of human neurokinin-3 receptor."FEBS Lett. 299:90-95(1992) [PubMed] [Europe PMC] [Abstract]
- "The primary structure and gene organization of human substance P and neuromedin K receptors."Eur. J. Biochem. 204:1025-1033(1992) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction."Nat. Genet. 41:354-358(2009) [PubMed] [Europe PMC] [Abstract]
- "Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism." Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]
- "The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients." J. Clin. Endocrinol. Metab. 99:E2138-2143(2014) [PubMed] [Europe PMC] [Abstract]