Dopamine Receptor D5 (DRD5)

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DR-D5; DBDR; DRD1B; DRD1L2; D1beta dopamine receptor

Dopamine Receptor D5 (DRD5)

D(1B) dopamine receptor is a protein of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2.The D1 and D5 receptors have a high degree of structural homology and few ligands are available that can distinguish between them as yet, however there are a number of ligands that are selective for D1/5 over the other dopamine receptors. The recent development of a selective D5 antagonist has allowed the action of D1-mediated responses to be studied in the absence of a D5 component, but no selective D5 agonists are yet available.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dopamine Receptor D5 (DRD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dopamine Receptor D5 (DRD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dopamine Receptor D5 (DRD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dopamine Receptor D5 (DRD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dopamine Receptor D5 (DRD5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dopamine Receptor D5 (DRD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dopamine Receptor D5 (DRD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dopamine Receptor D5 (DRD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dopamine Receptor D5 (DRD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dopamine Receptor D5 (DRD5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dopamine Receptor D5 (DRD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dopamine Receptor D5 (DRD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dopamine Receptor D5 (DRD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dopamine Receptor D5 (DRD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dopamine Receptor D5 (DRD5) ELISA Kit Customized Service Offer
  1. "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1."Nature 350:614-619(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes."Proc. Natl. Acad. Sci. U.S.A. 88:9175-9179(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene."J. Biol. Chem. 266:22427-22435(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells."Mol. Pharmacol. 56:1071-1078(1999) [PubMed] [Europe PMC] [Abstract]
  7. "A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm."Neurology 58:124-126(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease."Hum. Mol. Genet. 4:507-514(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  10. ErratumNat. Genet. 23:373-373(1999)