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Neuroglobin (NGB)

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Neuroglobin (NGB)
CCC A606
HGNC 14077
MGI 2151886
PubMed 12435404
RGD 621461
UniProt Q9NPG2
Wiki Neuroglobin

Neuroglobin is a newly discovered member of the hemoglobin superfamily that is primarily expressed in the brain of humans and other vertebrates. It is an O2-binding protein localized to cerebral neurons of vertebrates, including humans. Its physiological role is unknown but, like hemoglobin, myoglobin, and cytoglobin/histoglobin, it may transport O2, detoxify reactive oxygen species, or serve as a hypoxia sensor.Neuroglobin is a member of the vertebrate globin family involved in cellular oxygen homeostasis. It is an intracellular hemoprotein expressed in the central and peripheral nervous system, cerebrospinal fluid, retina and endocrine tissues. Italian researchers suggest that neuroglobin is more likely to usher in nitric oxide to protect neuron survival and recovery in areas where oxygen supply is reduced.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA606Hu01 Recombinant Neuroglobin (NGB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA606Hu01 Polyclonal Antibody to Neuroglobin (NGB) WB; IHC; ICC; IP.
MAA606Hu22 Monoclonal Antibody to Neuroglobin (NGB) WB; IHC; ICC; IP.
Assay Kits SEA606Hu ELISA Kit for Neuroglobin (NGB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA606Mu01 Recombinant Neuroglobin (NGB) Positive Control; Immunogen; SDS-PAGE; WB.
RPA606Mu02 Recombinant Neuroglobin (NGB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA606Mu01 Polyclonal Antibody to Neuroglobin (NGB) WB; IHC; ICC; IP.
PAA606Mu02 Polyclonal Antibody to Neuroglobin (NGB) WB; IHC; ICC; IP.
Assay Kits SEA606Mu ELISA Kit for Neuroglobin (NGB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA606Ra01 Recombinant Neuroglobin (NGB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA606Ra01 Polyclonal Antibody to Neuroglobin (NGB) WB; IHC; ICC; IP.
MAA606Ra21 Monoclonal Antibody to Neuroglobin (NGB) WB; IHC; ICC; IP.
Assay Kits SEA606Ra ELISA Kit for Neuroglobin (NGB) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A vertebrate globin expressed in the brain."Nature 407:520-522(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Full-length cDNA cloning of human neuroglobin and tissue expression of rat neuroglobin."Biochem. Biophys. Res. Commun. 290:1411-1419(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family."J. Biol. Chem. 276:38949-38955(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Coupling of the heme and an internal disulfide bond in human neuroglobin."Micron 35:59-62(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Zebrafish neuroglobin is a cell-membrane-penetrating globin."Biochemistry 47:5266-5270(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A role for human neuroglobin in apoptosis."IUBMB Life 62:878-885(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Human neuroglobin functions as a redox-regulated nitrite reductase."J. Biol. Chem. 286:18277-18289(2011) [PubMed] [Europe PMC] [Abstract]
  10. "14-3-3 binding and phosphorylation of neuroglobin during hypoxia modulate six-to-five heme pocket coordination and rate of nitrite reduction to nitric oxide."J. Biol. Chem. 286:42679-42689(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity."Structure 11:1087-1095(2003) [PubMed] [Europe PMC] [Abstract]