Serum Response Factor (SRF)

[Edit]

MCM1; C-Fos Serum Response Element-Binding Transcription Factor

Serum Response Factor (SRF)

SRF is a member of the MADS box superfamily of transcription factors.This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation.
SRF is considered very important during the development of the embryo, as it has been linked to the formation of mesoderm. In the fully developed mammal, SRF is crucial for the growth of skeletal muscle. Interaction of SRF with other proteins, such as steroid hormone receptors, may contribute to regulation of muscle growth by steroids.Lack of skin SRF is associated with psoriasis and other skin diseases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA515Hu01 Recombinant Serum Response Factor (SRF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA515Hu01 Polyclonal Antibody to Serum Response Factor (SRF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Serum Response Factor (SRF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serum Response Factor (SRF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serum Response Factor (SRF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serum Response Factor (SRF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serum Response Factor (SRF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serum Response Factor (SRF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serum Response Factor (SRF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serum Response Factor (SRF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serum Response Factor (SRF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serum Response Factor (SRF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serum Response Factor (SRF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serum Response Factor (SRF) ELISA Kit Customized Service Offer
  1. "Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element."Cell 55:989-1003(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "C-terminal phosphorylation of the serum-response factor."Eur. J. Biochem. 216:469-475(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties."EMBO J. 11:1045-1054(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Localization of O-GlcNAc modification on the serum response transcription factor."J. Biol. Chem. 267:16911-16921(1992) [PubMed] [Europe PMC] [Abstract]
  7. "The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites."J. Biol. Chem. 268:21147-21154(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin."Dev. Cell 9:261-270(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription."Circ. Res. 102:1502-1511(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin."Nat. Cell Biol. 11:557-568(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structure of serum response factor core bound to DNA."Nature 376:490-498(1995) [PubMed] [Europe PMC] [Abstract]