Calcitonin (CT)

[Edit]

CALCA; CALC1; CGRP-I; CGRP1; KC; CCP; PDN-21; Katacalcin; Calcitonin-Related Polypeptide Alpha; Calcitonin carboxyl-terminal peptide

Calcitonin (CT)

The most prominent clinical syndrome associated with a disordered hypersecretion of Calcitonin is medullary carcinoma of the thyroid (MTC). MTC is a tumor of the Calcitonin producing C-cells of the thyroid gland. Although MTC is rare, comprising 5 - 10% of all thyroid cancer, it is often fatal. It may occur sporadically or in a familial form that is transmitted as an autosomal dominant trait. MTC has great clinical importance because of its familial distribution. Further, it leant itself to be diagnosed early by serum Calcitonin and total cure for early sub-clinical disease is possible1. This is frequently associated with other clinical features and it has good potential for cure with surgery. Although a rare tumor, it can occur in a familial pattern1 as a Type II multiple endocrine neoplasia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA472Hu01 Recombinant Calcitonin (CT) Positive Control; Immunogen; SDS-PAGE; WB.
SPA472Hu01 Synthetic Calcitonin (CT) Immunogen; Blocking Peptide.
CPA472Hu21 OVA Conjugated Calcitonin (CT) Immunogen; SDS-PAGE; WB.
CPA472Hu11 BSA Conjugated Calcitonin (CT) Immunogen; SDS-PAGE; WB.
Antibodies PAA472Hu01 Polyclonal Antibody to Calcitonin (CT) WB; IHC; ICC; IP.
MAA472Hu22 Monoclonal Antibody to Calcitonin (CT) WB; IHC; ICC; IP.
LAA472Hu71 Biotin-Linked Polyclonal Antibody to Calcitonin (CT) WB; IHC; ICC.
PAA472Hu02 Polyclonal Antibody to Calcitonin (CT) WB; IHC; ICC; IP.
Assay Kits CEA472Hu ELISA Kit for Calcitonin (CT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA472Mu01 Recombinant Calcitonin (CT) Positive Control; Immunogen; SDS-PAGE; WB.
RPA472Mu02 Recombinant Calcitonin (CT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA472Mu01 Polyclonal Antibody to Calcitonin (CT) WB; IHC; ICC; IP.
PAA472Mu02 Polyclonal Antibody to Calcitonin (CT) WB; IHC; ICC; IP.
Assay Kits CEA472Mu ELISA Kit for Calcitonin (CT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA472Ra01 Recombinant Calcitonin (CT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA472Ra01 Polyclonal Antibody to Calcitonin (CT) WB; IHC; ICC; IP.
MAA472Ra21 Monoclonal Antibody to Calcitonin (CT) WB; IHC; ICC; IP.
Assay Kits CEA472Ra ELISA Kit for Calcitonin (CT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA472Ca01 Recombinant Calcitonin (CT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA472Ca01 Polyclonal Antibody to Calcitonin (CT) WB; IHC; ICC; IP.
MAA472Ca21 Monoclonal Antibody to Calcitonin (CT) WB; IHC; ICC; IP.
Assay Kits CEA472Ca ELISA Kit for Calcitonin (CT) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The complete sequence of human preprocalcitonin."FEBS Lett. 167:93-97(1984) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression."Proc. Natl. Acad. Sci. U.S.A. 82:1994-1998(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Expression and function of the human calcitonin/alpha-CGRP gene in health and disease."Biochem. Soc. Symp. 52:91-105(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Ectopic synthesis of high-Mr calcitonin by the BEN lung carcinoma cell line reflects aberrant proteolytic processing."FEBS Lett. 198:71-79(1986) [PubMed] [Europe PMC] [Abstract]
  5. "A novel calcitonin carboxyl-terminal peptide produced in medullary thyroid carcinoma by alternative RNA processing of the calcitonin/calcitonin gene-related peptide gene."J. Biol. Chem. 266:24627-24631(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide."Biochem. Biophys. Res. Commun. 123:648-655(1984) [PubMed] [Europe PMC] [Abstract]
  9. "Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma."EMBO J. 4:715-724(1985) [PubMed] [Europe PMC] [Abstract]
  10. "Human calcitonin. Structure of calcitonin M and D."Helv. Chim. Acta 51:1900-1905(1968) [PubMed] [Europe PMC] [Abstract]
  11. "A 1H NMR study of human calcitonin in solution."Biochemistry 30:2364-2371(1991) [PubMed] [Europe PMC] [Abstract]
  12. "Katacalcin: a new plasma calcium-lowering hormone."Lancet 1:846-848(1983) [PubMed] [Europe PMC] [Abstract]
  13. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]