Platelet Derived Growth Factor AB (PDGFAB)

Two types of PDGFRs have been identified: alpha type and beta type PDGFRs. The alpha type binds to PDGF-AA, PDGF-BB and PDGF-AB while the beta type PDGFR binds with high affinity to PDGF-BB and PDGF-AB. Upon activation by PDGF, these receptors dimerise, and are "switched on" by auto-phosphorylation of several sites on their cytosolic domains, which serve to mediate binding of cofactors and subsequently activate signal transduction, for example, through the PI3K pathway.  The different ligand isoforms have variable affinities for the receptor isoforms, and the receptor isoforms may variably form hetero- or homo- dimers. This leads to specificity of downstream signalling. It has been shown that the cis oncogene is derived from the PDGF B-chain gene. PDGF-BB is the highest-affinity ligand for the PDGFR-beta; PDGFR-beta is a key marker of hepatic stellate cell activation in the process of fibrogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Platelet Derived Growth Factor AB (PDGFAB) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Platelet Derived Growth Factor AB (PDGFAB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Platelet Derived Growth Factor AB (PDGFAB) Polyclonal Antibody Customized Service Offer
Assay Kits SEA436Hu ELISA Kit for Platelet Derived Growth Factor AB (PDGFAB) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA436Hu CLIA Kit for Platelet Derived Growth Factor AB (PDGFAB) Chemiluminescent immunoassay for Antigen Detection.