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Sirtuin 2 (SIRT2)

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SIR2L; SIR2-L; SIR2L2; Silent Information Regulator 2 Protein; NAD-Dependent Deacetylase Sirtuin-2; Silent Mating Type Information Regulation 2 Homolog

Sirtuin 2 (SIRT2)
CCC A430
HGNC 10886
MGI 1927664
PubMed 17588900
RGD 621481
UniProt Q8IXJ6
Wiki SIRT2

Sirtuin 2(silent mating type information regulation 2 homolog) 2 (S. cerevisiae), also known as SIRT2, is a human gene.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA430Hu01 Recombinant Sirtuin 2 (SIRT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA430Hu01 Polyclonal Antibody to Sirtuin 2 (SIRT2) WB; IHC; ICC; IP.
MAA430Hu22 Monoclonal Antibody to Sirtuin 2 (SIRT2) WB; IHC; ICC; IP.
Assay Kits SEA430Hu ELISA Kit for Sirtuin 2 (SIRT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA430Mu01 Recombinant Sirtuin 2 (SIRT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA430Mu01 Polyclonal Antibody to Sirtuin 2 (SIRT2) WB; IHC; ICC; IP.
Assay Kits SEA430Mu ELISA Kit for Sirtuin 2 (SIRT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA430Ra01 Recombinant Sirtuin 2 (SIRT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA430Ra01 Polyclonal Antibody to Sirtuin 2 (SIRT2) WB; IHC; ICC; IP.
LAA430Ra71 Biotin-Linked Polyclonal Antibody to Sirtuin 2 (SIRT2) WB; IHC; ICC.
Assay Kits SEA430Ra ELISA Kit for Sirtuin 2 (SIRT2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity."Biochem. Biophys. Res. Commun. 260:273-279(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2."Gene 234:161-168(1999) [PubMed] [Europe PMC] [Abstract]
  3. "A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression."J. Neurochem. 81:575-588(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform."J. Mol. Biol. 426:1677-1691(2014) [PubMed] [Europe PMC] [Abstract]
  5. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast."EMBO J. 20:197-209(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening."J. Biol. Chem. 276:38837-38843(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases."J. Biol. Chem. 277:12632-12641(2002) [PubMed] [Europe PMC] [Abstract]
  11. "The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase."Mol. Cell 11:437-444(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle."Mol. Cell. Biol. 23:3173-3185(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene."Biochem. Biophys. Res. Commun. 309:558-566(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10."J. Biochem. 135:695-700(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins."Mol. Biol. Cell 16:4623-4635(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  17. "SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis."Genes Dev. 20:1256-1261(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation."J. Biol. Chem. 282:19546-19555(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin."Mol. Cell. Biochem. 303:221-230(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation."Neuroscience 147:599-612(2007) [PubMed] [Europe PMC] [Abstract]
  21. "SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress."Oncogene 26:945-957(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis."PLoS ONE 2:E784-E784(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53."Biochem. Biophys. Res. Commun. 368:690-695(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Acetylation of Sirt2 by p300 attenuates its deacetylase activity."Biochem. Biophys. Res. Commun. 375:576-580(2008) [PubMed] [Europe PMC] [Abstract]
  25. "SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 zeta and BAD in H9c2 cells."FEBS Lett. 582:2857-2862(2008) [PubMed] [Europe PMC] [Abstract]
  26. "The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility."J. Cell Biol. 180:915-929(2008) [PubMed] [Europe PMC] [Abstract]
  27. "The SIRT2 deacetylase regulates autoacetylation of p300."Mol. Cell 32:449-455(2008) [PubMed] [Europe PMC] [Abstract]
  28. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  29. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  30. "SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest."Cell Cycle 8:1279-1291(2009) [PubMed] [Europe PMC] [Abstract]
  31. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  32. "p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals."J. Biol. Chem. 285:28553-28564(2010) [PubMed] [Europe PMC] [Abstract]
  33. "SIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310."J. Cell Sci. 123:4251-4258(2010) [PubMed] [Europe PMC] [Abstract]
  34. "Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity."Nat. Cell Biol. 12:665-675(2010) [PubMed] [Europe PMC] [Abstract]
  35. "SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity."Cancer Cell 20:487-499(2011) [PubMed] [Europe PMC] [Abstract]
  36. "The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS."Hum. Mol. Genet. 20:3986-3996(2011) [PubMed] [Europe PMC] [Abstract]
  37. "Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase."Mol. Cell 43:33-44(2011) [PubMed] [Europe PMC] [Abstract]
  38. "Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling."Proc. Natl. Acad. Sci. U.S.A. 108:E952-961(2011) [PubMed] [Europe PMC] [Abstract]
  39. "Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A)."FEBS Lett. 586:3236-3241(2012) [PubMed] [Europe PMC] [Abstract]
  40. "SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition."Neurochem. Int. 61:992-1000(2012) [PubMed] [Europe PMC] [Abstract]
  41. "SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis."Transl. Cancer Res. 1:15-21(2012) [PubMed] [Europe PMC] [Abstract]
  42. "ERK1/2 regulates SIRT2 deacetylase activity."Biochem. Biophys. Res. Commun. 437:245-249(2013) [PubMed] [Europe PMC] [Abstract]
  43. "The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation."Genes Dev. 27:639-653(2013) [PubMed] [Europe PMC] [Abstract]
  44. "Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth."Mol. Cell 51:506-518(2013) [PubMed] [Europe PMC] [Abstract]
  45. "A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection."Science 341:1238858-1238858(2013) [PubMed] [Europe PMC] [Abstract]
  46. "Regulation of G6PD acetylation by KAT9/SIRT2 modulates NADPH homeostasis and cell survival during oxidative stress."EMBO J. 33:1304-1320(2014) [PubMed] [Europe PMC] [Abstract]
  47. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  48. "SIRT2 regulates tumour hypoxia response by promoting HIF-1alpha hydroxylation."Oncogene 34:1354-1362(2015) [PubMed] [Europe PMC] [Abstract]
  49. "Structure of the histone deacetylase SIRT2."Nat. Struct. Biol. 8:621-625(2001) [PubMed] [Europe PMC] [Abstract]
  50. "Crystal structure analysis of human Sirt2 and its ADP-ribose complex."J. Struct. Biol. 182:136-143(2013) [PubMed] [Europe PMC] [Abstract]
  51. "Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change."Structure 22:345-352(2014) [PubMed] [Europe PMC] [Abstract]