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Apobec 1 Complementation Factor (ACF)

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ASP; ACF64; ACF65; A1CF; APOBEC1CF; Apolipoprotein B MRNA Editing Enzyme Catalytic Polypeptide 1 Complementation Factor; APOBEC1-stimulating protein

Apobec 1 Complementation Factor (ACF)
CCC A426
HGNC 24086
MGI 1917115
PubMed 10669759
RGD 619834
UniProt Q9NQ94
Wiki ACF

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA426Hu01 Recombinant Apobec 1 Complementation Factor (ACF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA426Hu01 Polyclonal Antibody to Apobec 1 Complementation Factor (ACF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Apobec 1 Complementation Factor (ACF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apobec 1 Complementation Factor (ACF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA426Mu01 Recombinant Apobec 1 Complementation Factor (ACF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Apobec 1 Complementation Factor (ACF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apobec 1 Complementation Factor (ACF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apobec 1 Complementation Factor (ACF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apobec 1 Complementation Factor (ACF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apobec 1 Complementation Factor (ACF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apobec 1 Complementation Factor (ACF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apobec 1 Complementation Factor (ACF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apobec 1 Complementation Factor (ACF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apobec 1 Complementation Factor (ACF) ELISA Kit Customized Service Offer
  1. "Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex."J. Biol. Chem. 275:19848-19856(2000) [PubMed] [Europe PMC] [Abstract] and Small intestine.
  2. "Molecular cloning of APOBEC-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA."Mol. Cell. Biol. 20:1846-1854(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing."J. Biol. Chem. 276:10272-10283(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation, characterization and developmental regulation of the human apobec-1 complementation factor (ACF) gene."Biochim. Biophys. Acta 1522:22-30(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing."RNA 8:69-82(2002) [PubMed] [Europe PMC] [Abstract]
  9. "The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay."EMBO J. 22:3971-3982(2003) [PubMed] [Europe PMC] [Abstract]
  10. "A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling."J. Biol. Chem. 278:41198-41204(2003) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of the RNA recognition motif of human APOBEC-1 complementation factor, ACF."Submitted (NOV-2005) to the PDB data bank