Neurogranin (NRGN)

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Ng; NEUG; Protein Kinase C Substrate RC3

Neurogranin (NRGN)
Neurogranin is a calmodulin-binding protein expressed exclusively in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium. Phosphorylation by protein kinase C lowers its binding ability. NRGN gene expression is controlled by thyroid hormones. One study tells of potential link of neurogranin gene to the heightened risk of schizophrenia in males, another study gives evidence of lowered neurogranin immunoreactivity in the brains of people suffering from schizophrenia.Prior to its identification in the bovine and rat brain in 1991, neurogranin was known as a putative protein kinase C-phosphorylated protein named p17.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA404Hu01 Recombinant Neurogranin (NRGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA404Hu01 Polyclonal Antibody to Neurogranin (NRGN) WB; IHC; ICC; IP.
MAA404Hu22 Monoclonal Antibody to Neurogranin (NRGN) WB; IHC; ICC; IP.
Assay Kits CEA404Hu ELISA Kit for Neurogranin (NRGN) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA404Mi ELISA Kit for Neurogranin (NRGN) Enzyme-linked immunosorbent assay for Antigen Detection.
CEA404Mi ELISA Kit for Neurogranin (NRGN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurogranin (NRGN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurogranin (NRGN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurogranin (NRGN) Polyclonal Antibody Customized Service Offer
Assay Kits SEA404Mi ELISA Kit for Neurogranin (NRGN) Enzyme-linked immunosorbent assay for Antigen Detection.
CEA404Mi ELISA Kit for Neurogranin (NRGN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurogranin (NRGN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurogranin (NRGN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurogranin (NRGN) Polyclonal Antibody Customized Service Offer
Assay Kits SEA404Mi ELISA Kit for Neurogranin (NRGN) Enzyme-linked immunosorbent assay for Antigen Detection.
CEA404Mi ELISA Kit for Neurogranin (NRGN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning cDNA for human neurogranin."Bioorg. Khim. 22:366-369(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and chromosomal localization of human neurogranin gene."Bioorg. Khim. 23:961-968(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN)."Genomics 41:243-249(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia."J. Neuropathol. Exp. Neurol. 56:1105-1118(1997) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and Characterization of citrulline-modified brain proteins by combining HCD and CID fragmentation."Proteomics 13:2682-2691(2013) [PubMed] [Europe PMC] [Abstract]