Mucin 17 (MUC17)


MUC3; Mucin Cell Surface Associated; Small intestinal mucin-3

Mucin 17 (MUC17)

Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.

By microarray analysis, Moehle et al. (2006) found coordinated downregulation of mucins, including MUC17, in colon of patients with inflammatory bowel disease (IBD), including Crohn disease and ulcerative colitis, compared with controls. They identified an NF-kappa-B-binding site in the MUC17 promoter and showed that activation of the NF-kappa-B signaling pathway by inflammatory cytokines TNF-alpha (TNF) and TGF-beta (TGFB1) upregulated MUC17 mRNA expression about 2-fold and 3-fold, respectively.

Organism species: Homo sapiens (Human)

Proteins RPA403Hu01 Recombinant Mucin 17 (MUC17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA403Hu01 Polyclonal Antibody to Mucin 17 (MUC17) WB; IHC; ICC; IP.
MAA403Hu22 Monoclonal Antibody to Mucin 17 (MUC17) WB; IHC; ICC; IP.
Assay Kits SEA403Hu ELISA Kit for Mucin 17 (MUC17) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Characterization of human mucin MUC17. Complete coding sequence and organization."J. Biol. Chem. 281:23676-23685(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region."Biochem. Biophys. Res. Commun. 238:143-148(1997) [PubMed] [Europe PMC] [Abstract]
  4. "MUC17, a novel membrane-tethered mucin."Biochem. Biophys. Res. Commun. 291:466-475(2002) [PubMed] [Europe PMC] [Abstract]
  5. "N-glycosylation is required for the surface localization of MUC17 mucin."Int. J. Oncol. 23:585-592(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine."Biochem. J. 410:283-289(2008) [PubMed] [Europe PMC] [Abstract]