B-Cell Activation Factor Receptor (BAFFR)

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CD268; TNFRSF13C; TNFRSF13-C; BAFF-R; BAFFR; BR3; Tumor Necrosis Factor Receptor Superfamily Member 13C

B-Cell Activation Factor Receptor (BAFFR)

BAFF receptor is a recently identified molecule that specifically binds BLyS, a protein belonging to the tumor necrosis factor (TNF) family, and is involved in survival and maturation of B cells. Recent studies have demonstrated that mice defective in BAFF-R gene exhibit an altered profile of the B cell pool, a phenotype observed in BLyS knockout mice as well. These features suggest that mutations in this gene may result in humoral immunodeficiency.

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA281Hu01 Recombinant B-Cell Activation Factor Receptor (BAFFR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA281Hu02 Recombinant B-Cell Activation Factor Receptor (BAFFR) Positive Control; Immunogen; SDS-PAGE; WB.
APA281Hu01 Active B-Cell Activation Factor Receptor (BAFFR) Cell culture; Activity Assays.
Antibodies PAA281Hu01 Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) WB; IHC; ICC; IP.
MAA281Hu22 Monoclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) WB; IHC; ICC; IP.
LAA281Hu81 FITC-Linked Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) WB; IHC; ICC; IF.
LAA281Hu71 Biotin-Linked Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) WB; IHC; ICC.
PAA281Hu02 Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits SEA281Hu ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA281Mu01 Recombinant B-Cell Activation Factor Receptor (BAFFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA281Mu01 Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA281Ra01 Recombinant B-Cell Activation Factor Receptor (BAFFR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA281Ra02 Recombinant B-Cell Activation Factor Receptor (BAFFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA281Ra01 Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) WB; IHC; ICC; IP.
LAA281Ra71 Biotin-Linked Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) WB; IHC; ICC.
PAA281Ra02 Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA281Ga01 Recombinant B-Cell Activation Factor Receptor (BAFFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA281Ga01 Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) ELISA Kit Customized Service Offer
  1. "BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF."Science 293:2108-2111(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency."Curr. Biol. 11:1547-1552(2001) [PubMed] [Europe PMC] [Abstract]
  4. "BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2."Immunity 17:515-524(2002) [PubMed] [Europe PMC] [Abstract]
  5. "BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site."Biochemistry 42:5977-5983(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Ligand-receptor binding revealed by the TNF family member TALL-1."Nature 423:49-56(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation."Nat. Struct. Biol. 10:342-348(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells."Blood 108:3103-3111(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency."J. Clin. Immunol. 25:496-502(2005) [PubMed] [Europe PMC] [Abstract]
  10. "B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans."Proc. Natl. Acad. Sci. U.S.A. 106:13945-13950(2009) [PubMed] [Europe PMC] [Abstract]