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Poly ADP Ribose Polymerase (PARP)

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PARP1; ADPRT; ADPRT1; PPOL; pADPRT-1; ADP-ribosyltransferase diphtheria toxin-like 1; NAD(+) ADP-ribosyltransferase 1

Poly ADP Ribose Polymerase (PARP)
CCC A279
HGNC 270
MGI 1340806
PubMed 16123586
RGD 2053
UniProt P09874
Wiki PARP1
is a protein involved in a number of cellular processes involving mainly DNA repair and programmed cell death.RP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress . This protein can be cleaved by many ICE-like caspases in vitroand is one of the main cleavage targets of caspase-3 in vivo . In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) .
PARP1 is a chromatin-associated enzyme, poly-ADP ribose polymerase-1, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA279Hu01 Recombinant Poly ADP Ribose Polymerase (PARP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA279Hu01 Polyclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
MAA279Hu21 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
MAA279Hu22 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
MAA279Hu23 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
MAA279Hu24 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
MAA279Hu25 Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
Assay Kits SEA279Hu ELISA Kit for Poly ADP Ribose Polymerase (PARP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA279Hu CLIA Kit for Poly ADP Ribose Polymerase (PARP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA279Mu01 Recombinant Poly ADP Ribose Polymerase (PARP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA279Mu01 Polyclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
Assay Kits SEA279Mu ELISA Kit for Poly ADP Ribose Polymerase (PARP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poly ADP Ribose Polymerase (PARP) Recombinant Protein Customized Service Offer
Antibodies PAA279Ra01 Polyclonal Antibody to Poly ADP Ribose Polymerase (PARP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Poly ADP Ribose Polymerase (PARP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly ADP Ribose Polymerase (PARP) ELISA Kit Customized Service Offer
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  9. , Submitted (DEC-2008) to UniProtKB
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  27. "Poly(ADP-ribose) polymerase-1 (PARP-1) transcriptionally regulates angiotensin AT2 receptor (AT2R) and AT2R binding protein (ATBP) genes."Biochem. Pharmacol. 77:1795-1805(2009) [PubMed] [Europe PMC] [Abstract]
  28. "PARP-1 transcriptional activity is regulated by sumoylation upon heat shock."EMBO J. 28:3534-3548(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  30. "Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1."Science 325:1240-1243(2009) [PubMed] [Europe PMC] [Abstract]
  31. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
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  34. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  35. "Poly(ADP-ribose)-dependent regulation of Snail1 protein stability."Oncogene 30:4365-4372(2011) [PubMed] [Europe PMC] [Abstract]
  36. "Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling."PLoS ONE 6:E22595-E22595(2011) [PubMed] [Europe PMC] [Abstract]
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  40. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  41. "BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8."Mol. Cell. Biol. 33:845-857(2013) [PubMed] [Europe PMC] [Abstract]
  42. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  43. "Solution structure of the first ZF-PARP domain, of the BRCT domain and of the WGR domain of human poly(ADP-ribose)polymerase-1."Submitted (APR-2007) to the PDB data bank
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