Talin (TLN)

TALIN is a high-molecular-weight cytoskeletal protein concentrated at regions of cell-substratum contactand, in lymphocytes, at cell-cell contacts.Talin-1 is a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA278Hu01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA278Hu02 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA278Hu01 Polyclonal Antibody to Talin (TLN) WB; ICC; IHC-P; IHC-F; ELISA.
MAA278Hu22 Monoclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
LAA278Hu81 FITC-Linked Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IF.
LAA278Hu71 Biotin-Linked Polyclonal Antibody to Talin (TLN) WB; IHC; ICC.
PAA278Hu02 Polyclonal Antibody to Talin (TLN) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits SEA278Hu ELISA Kit for Talin (TLN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA278Mu01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA278Mu01 Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
Assay Kits SEA278Mu ELISA Kit for Talin (TLN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA278Ra01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA278Ra01 Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Talin (TLN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Talin (TLN) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA278Ga01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA278Ga01 Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Talin (TLN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Talin (TLN) ELISA Kit Customized Service Offer

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA278Fi01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA278Fi01 Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Talin (TLN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Talin (TLN) ELISA Kit Customized Service Offer
  1. "Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern."Genomics 62:316-319(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (NOV-2005) to UniProtKB
  7. "Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks."Biochemistry 38:6135-6143(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions."Nature 420:89-93(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha."J. Biol. Chem. 278:6567-6574(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin."Exp. Cell Res. 314:1839-1849(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition."J. Cell Biol. 194:307-322(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells."Cell Host Microbe 16:201-214(2014) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Structural basis for amplifying vinculin activation by talin."J. Biol. Chem. 279:27667-27678(2004) [PubMed] [Europe PMC] [Abstract]