Cyclophilin B (CYPB)

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PPIB; PPI-B; CYP-S1; CyP-B; SCYLP; PPIase B; Rotamase B; S-cyclophilin; Peptidylprolyl Isomerase B; Peptidyl-Prolyl Cis-Trans Isomerase B

Cyclophilin B (CYPB)

Cyclophilin B (CyPB) is a member of the cyclophilin family with specific N- and C-terminal extensions. CyPB is a heparin-binding protein first identified as a receptor for cyclosporin A(CsA). CsA blocks helper T-cell activation at a step between T-cell receptor stimulation and the transcriptional activation of cytokine genes. Cyclophilins from many species possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that is blocked by CsA and therefore may be relevant in CsA-mediated immunosuppression. Unlike CyPA, CyPB has a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA227Hu01 Recombinant Cyclophilin B (CYPB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA227Hu01 Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC; IP.
MAA227Hu22 Monoclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC; IP.
LAA227Hu71 Biotin-Linked Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC.
Assay Kits SEA227Hu ELISA Kit for Cyclophilin B (CYPB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA227Mu01 Recombinant Cyclophilin B (CYPB) Positive Control; Immunogen; SDS-PAGE; WB.
RPA227Mu02 Recombinant Cyclophilin B (CYPB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA227Mu01 Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC; IP.
LAA227Mu71 Biotin-Linked Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC.
PAA227Mu02 Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC; IP.
Assay Kits SEA227Mu ELISA Kit for Cyclophilin B (CYPB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA227Ra01 Recombinant Cyclophilin B (CYPB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA227Ra01 Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC; IP.
LAA227Ra71 Biotin-Linked Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC.
LAA227Ra81 FITC-Linked Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC; IF.
MAA227Ra21 Monoclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC; IP.
Assay Kits SEA227Ra ELISA Kit for Cyclophilin B (CYPB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA227Rb01 Recombinant Cyclophilin B (CYPB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA227Rb51 Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cyclophilin B (CYPB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclophilin B (CYPB) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA227Bo01 Recombinant Cyclophilin B (CYPB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA227Bo01 Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cyclophilin B (CYPB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclophilin B (CYPB) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA227Ga01 Recombinant Cyclophilin B (CYPB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA227Ga01 Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC; IP.
LAA227Ga71 Biotin-Linked Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC.
LAA227Ga81 FITC-Linked Polyclonal Antibody to Cyclophilin B (CYPB) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Cyclophilin B (CYPB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclophilin B (CYPB) ELISA Kit Customized Service Offer
  1. "A novel secreted cyclophilin-like protein (SCYLP)."J. Biol. Chem. 266:10735-10738(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence."Proc. Natl. Acad. Sci. U.S.A. 88:1903-1907(1991) [PubMed] [Europe PMC] [Abstract]
  6. "An endoplasmic reticulum-specific cyclophilin."Mol. Cell. Biol. 11:3484-3491(1991) [PubMed] [Europe PMC] [Abstract]