Alpha-1-Microglobulin/Bikunin Precursor (a1M)

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AMBP; UTI; HCP; EDC1; HI30; IATIL; ITILC; ITI; ITIL; Alpha 1 Microglobulin/Bikunin Precursor; Growth-inhibiting protein 19; Uristatin; Uronic-Acid-Rich Protein; Trypstatin

Alpha-1-Microglobulin/Bikunin Precursor (a1M)

Alpha-1-microglobulin (A1M), also known as protein HC (for Heterogeneous Charge), is a low molecular weight protein component of plasma first discovered in pathological human urine. It is a member of the lipocalin superfamily. Although much is now known of its structure and properties, the function and physiological role of A1M remains unclear, although evidence suggests that it functions in the regulation of the immune system. A1M is known to exist in both a free form and complexed to other macromolecules: immunoglobulin A (IgA) in humans and alpha-1-inhibitor-3 in the rat. Free A1M is a monomeric protein composed of one 188 residue polypeptide and contains three cysteines, two of which (residues 75 and 173) form a conserved intra-molecular disulphide link.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA217Hu01 Recombinant Alpha-1-Microglobulin/Bikunin Precursor (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA217Hu01 Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC; IP.
MAA217Hu22 Monoclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC; IP.
LAA217Hu71 Biotin-Linked Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC.
Assay Kits SEA217Hu ELISA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA217Hu CLIA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA217Mu01 Recombinant Alpha-1-Microglobulin/Bikunin Precursor (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
RPA217Mu02 Recombinant Alpha-1-Microglobulin/Bikunin Precursor (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA217Mu01 Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC; IP.
LAA217Mu81 FITC-Linked Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC; IF.
LAA217Mu71 Biotin-Linked Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC.
PAA217Mu02 Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC; IP.
Assay Kits SEA217Mu ELISA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) Enzyme-linked immunosorbent assay for Antigen Detection.
CEA217Mu ELISA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA217Ra01 Recombinant Alpha-1-Microglobulin/Bikunin Precursor (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
RPA217Ra02 Recombinant Alpha-1-Microglobulin/Bikunin Precursor (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA217Ra01 Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC; IP.
LAA217Ra81 FITC-Linked Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC; IF.
LAA217Ra71 Biotin-Linked Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC.
PAA217Ra02 Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC; IP.
Assay Kits SEA217Ra ELISA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA217Gu01 Recombinant Alpha-1-Microglobulin/Bikunin Precursor (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA217Gu01 Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA217Po01 Recombinant Alpha-1-Microglobulin/Bikunin Precursor (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA217Po01 Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA217Bo01 Recombinant Alpha-1-Microglobulin/Bikunin Precursor (a1M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA217Bo01 Polyclonal Antibody to Alpha-1-Microglobulin/Bikunin Precursor (a1M) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-1-Microglobulin/Bikunin Precursor (a1M) ELISA Kit Customized Service Offer
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  21. "The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC."J. Biol. Chem. 266:15758-15763(1991) [PubMed] [Europe PMC] [Abstract]
  22. "Alpha1-microglobulin chromophores are located to three lysine residues semiburied in the lipocalin pocket and associated with a novel lipophilic compound."Protein Sci. 8:2611-2620(1999) [PubMed] [Europe PMC] [Abstract]
  23. "Human alpha-1-microglobulin is covalently bound to kynurenine-derived chromophores."J. Biol. Chem. 279:51033-51041(2004) [PubMed] [Europe PMC] [Abstract]
  24. "The ORF3 protein of hepatitis E virus interacts with liver-specific alpha1-microglobulin and its precursor alpha1-microglobulin/bikunin precursor (AMBP) and expedites their export from the hepatocyte."J. Biol. Chem. 279:29308-29319(2004) [PubMed] [Europe PMC] [Abstract]
  25. "The 41-amino-acid C-terminal region of the hepatitis E virus ORF3 protein interacts with bikunin, a Kunitz-type serine protease inhibitor."J. Virol. 79:12081-12087(2005) [PubMed] [Europe PMC] [Abstract]
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  29. "Alpha(1)-microglobulin: a yellow-brown lipocalin."Biochim. Biophys. Acta 1482:172-184(2000) [PubMed] [Europe PMC] [Abstract]