Pepsinogen A (PGA)

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PGA5; PG-A; Pepsinogen 5 Group I; Pepsinogen-5; Pepsin A-5

Pepsinogen A (PGA)

Pepsinogen A is secreted exclusively by the chief cells of the gastric corpus. The levels of Pepsinogen I correlate directly with the active number of chief cells in this area. In cases of severe atrophic gastritis of the corpus region, the chief cells will be destroyed and the levels of Pepsinogen I will fall dramatically.Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. It consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41-amino acid segment from the amino end. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Samloff and Townes (1970) showed that the pepsinogen-5 derived from the stomach and excreted in the urine is absent in some persons. Family and population data supported the view that absence of PG-5 is recessive.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA165Hu01 Recombinant Pepsinogen A (PGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA165Hu01 Polyclonal Antibody to Pepsinogen A (PGA) WB; IHC; ICC; IP.
MAA165Hu22 Monoclonal Antibody to Pepsinogen A (PGA) WB; IHC; ICC; IP.
LAA165Hu71 Biotin-Linked Polyclonal Antibody to Pepsinogen A (PGA) WB; IHC; ICC.
MAA165Hu21 Monoclonal Antibody to Pepsinogen A (PGA) WB; IHC; ICC; IP.
LAA165Hu72 Biotin-Linked Monoclonal Antibody to Pepsinogen A (PGA) WB; IHC; ICC.
Assay Kits SEA165Hu ELISA Kit for Pepsinogen A (PGA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pepsinogen A (PGA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pepsinogen A (PGA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pepsinogen A (PGA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pepsinogen A (PGA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pepsinogen A (PGA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA165Ra01 Recombinant Pepsinogen A (PGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA165Ra01 Polyclonal Antibody to Pepsinogen A (PGA) WB; IHC; ICC; IP.
LAA165Ra71 Biotin-Linked Polyclonal Antibody to Pepsinogen A (PGA) WB; IHC; ICC.
LAA165Ra81 FITC-Linked Polyclonal Antibody to Pepsinogen A (PGA) WB; IHC; ICC; IF.
MAA165Ra21 Monoclonal Antibody to Pepsinogen A (PGA) WB; IHC; ICC; IP.
Assay Kits SEA165Ra ELISA Kit for Pepsinogen A (PGA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA165Bo01 Recombinant Pepsinogen A (PGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA165Bo01 Polyclonal Antibody to Pepsinogen A (PGA) WB; IHC; ICC; IP.
MAA165Bo21 Monoclonal Antibody to Pepsinogen A (PGA) WB; IHC; ICC; IP.
Assay Kits SEA165Bo ELISA Kit for Pepsinogen A (PGA) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family."Genomics 4:232-239(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences."J. Biochem. 98:483-492(1985) [PubMed] [Europe PMC] [Abstract]
  5. "A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins."J. Biochem. 106:920-927(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Activation of human pepsinogens."FEBS Lett. 241:69-72(1988) [PubMed] [Europe PMC] [Abstract]
  7. "Carboxyl-terminal sequence of human gastricsin and pepsin."J. Biol. Chem. 245:2189-2193(1970) [PubMed] [Europe PMC] [Abstract]
  8. "Primary structure of human pepsinogen gene."J. Biol. Chem. 258:5306-5311(1983) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of human pepsin and its complex with pepstatin."Protein Sci. 4:960-972(1995) [PubMed] [Europe PMC] [Abstract]