Olfactomedin 4 (OLFM4)

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OLM4; hGC1; hOLfD; OlfD; GW112; GC1; G-CSF-stimulated clone 1 protein; Antiapoptotic protein GW112

Olfactomedin 4 (OLFM4)
Olfactomedin 4is an antiapoptotic factor, can promote tumor growth. It promotes proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. It Facilitates cell adhesion. OLFM4 expressed during myeloid lineage development.Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Highly expressed in pancreatic cancer tissues and shows an elevated expression level during the early S phase of the cell cycle. Also expressed at high levels in stomach cancer and colon cancer tissues.
OLFM4 was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. The protein encoded is a member of the olfactomedin-related protein family. The exact function of this gene has not yet been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA162Hu01 Recombinant Olfactomedin 4 (OLFM4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA162Hu01 Polyclonal Antibody to Olfactomedin 4 (OLFM4) WB; IHC; ICC; IP.
MAA162Hu22 Monoclonal Antibody to Olfactomedin 4 (OLFM4) WB; IHC; ICC; IP.
LAA162Hu71 Biotin-Linked Polyclonal Antibody to Olfactomedin 4 (OLFM4) WB; IHC; ICC.
Assay Kits SEA162Hu ELISA Kit for Olfactomedin 4 (OLFM4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA162Mu01 Recombinant Olfactomedin 4 (OLFM4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA162Mu02 Recombinant Olfactomedin 4 (OLFM4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA162Mu01 Polyclonal Antibody to Olfactomedin 4 (OLFM4) WB; IHC; ICC; IP.
LAA162Mu71 Biotin-Linked Polyclonal Antibody to Olfactomedin 4 (OLFM4) WB; IHC; ICC.
LAA162Mu81 FITC-Linked Polyclonal Antibody to Olfactomedin 4 (OLFM4) WB; IHC; ICC; IF.
PAA162Mu02 Polyclonal Antibody to Olfactomedin 4 (OLFM4) WB; IHC; ICC; IP.
Assay Kits SEA162Mu ELISA Kit for Olfactomedin 4 (OLFM4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA162Ra01 Recombinant Olfactomedin 4 (OLFM4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA162Ra01 Polyclonal Antibody to Olfactomedin 4 (OLFM4) WB; IHC; ICC; IP.
LAA162Ra71 Biotin-Linked Polyclonal Antibody to Olfactomedin 4 (OLFM4) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Olfactomedin 4 (OLFM4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Olfactomedin 4 (OLFM4) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA162Bo01 Recombinant Olfactomedin 4 (OLFM4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA162Bo01 Polyclonal Antibody to Olfactomedin 4 (OLFM4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Olfactomedin 4 (OLFM4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Olfactomedin 4 (OLFM4) ELISA Kit Customized Service Offer
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  2. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development."Gene 283:83-93(2002) [PubMed] [Europe PMC] [Abstract]
  5. "GW112, a novel antiapoptotic protein that promotes tumor growth."Cancer Res. 64:2474-2481(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The glycoprotein hGC-1 binds to cadherin and lectins."Exp. Cell Res. 312:1785-1797(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells."Cancer Sci. 98:334-340(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis."Blood 116:4938-4947(2010) [PubMed] [Europe PMC] [Abstract]