Alpha-2-Plasmin Inhibitor (a2PI)

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SERPINF2; AAP; A2-PI; API; PLI; A2AP; Alpha 2 Antiplasmin; Serpin Peptidase Inhibitor Clade F Member 2; Pigment Epithelium Derived Factor

Alpha-2-Plasmin Inhibitor (a2PI)

An inherited hemorrhagic diathesis due to plasmin inhibitor deficiency was described by Koie et al. (1978) in a 25-year-old Okinawa man. He had suffered prolonged bleeding and ecchymoses after minor trauma, spontaneous joint hemorrhage, and one episode of hemothorax. The bleeding episodes were reduced in frequency and severity by an antiplasminic drug. Laboratory abnormalities were limited to shortened euglobulin-lysis time and whole blood clot lysis time. No circulating alpha-2-plasmin inhibitor was found in the plasma. Even though only one case was observed, autosomal recessive inheritance was undoubted because the parents were consanguineous and both had plasma antiplasmin levels about half normal. The authors called the condition Miyasato disease after the proband's surname.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA160Hu01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA160Hu01 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
MAA160Hu22 Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
LAA160Hu71 Biotin-Linked Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC.
Assay Kits SEA160Hu ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA160Mu01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA160Mu01 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
LAA160Mu71 Biotin-Linked Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA160Ra01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA160Ra01 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA160Rb01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA160Rb51 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA160Bo01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA160Bo01 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) ELISA Kit Customized Service Offer
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  2. "Organization of the human alpha 2-plasmin inhibitor gene."Proc. Natl. Acad. Sci. U.S.A. 85:6836-6840(1988) [PubMed] [Europe PMC] [Abstract]
  3. ErratumProc. Natl. Acad. Sci. U.S.A. 86:1612-1613(1989)
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  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  10. "Amino-acid sequence of human alpha 2-antiplasmin."Eur. J. Biochem. 166:565-574(1987) [PubMed] [Europe PMC] [Abstract]
  11. "Purification and characterization of human antiplasmin, the fast-acting plasmin inhibitor in plasma."Eur. J. Biochem. 78:19-26(1977) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of the carboxyl-terminal half of human alpha 2-plasmin inhibitor deduced from that of cDNA."J. Biochem. 100:1399-1402(1986) [PubMed] [Europe PMC] [Abstract]
  13. "Sulfation of a tyrosine residue in the plasmin-binding domain of alpha 2-antiplasmin."J. Biol. Chem. 262:3082-3085(1987) [PubMed] [Europe PMC] [Abstract]
  14. "Alpha-2-antiplasmin: a serpin with two separate but overlapping reactive sites."Science 241:699-700(1988) [PubMed] [Europe PMC] [Abstract]
  15. "Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties."Biochem. J. 323:847-852(1997) [PubMed] [Europe PMC] [Abstract]
  16. "A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion."Blood 103:3783-3788(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity."Biochem. J. 390:231-242(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein."Blood 107:1397-1404(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Hereditary alpha 2-plasmin inhibitor deficiency caused by a transport-deficient mutation (alpha 2-PI-Okinawa). Deletion of Glu137 by a trinucleotide deletion blocks intracellular transport."J. Biol. Chem. 264:18213-18219(1989) [PubMed] [Europe PMC] [Abstract]
  21. "A novel missense mutation in the human plasmin inhibitor (alpha2-antiplasmin) gene associated with a bleeding tendency."Br. J. Haematol. 107:317-322(1999) [PubMed] [Europe PMC] [Abstract]