Carcinoembryonic Antigen (CEA)

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CD66E; CD66; CEACAM5; Carcinoembryonic Antigen-related Cell Adhesion Molecule 5; Carcinoembryonic Antigen

Carcinoembryonic Antigen (CEA)

Carcinoembryonic antigen (CEA) is a cell-surface glycoprotein with a molecular weight of 180-200kD, that occurs in high levels in colon epithelial cells during embryonic development. Levels of CEA are significantly lower in colon tissue of adults, but can become elevated when inflammation or tumours arise in any endodermal tissue, including the gastrointestinal tract, respiratory tract, pancreas and breast.An overexpression of CEA protein has been detected in a variety of adenocarcinomas, including gastric, pancreatic, small intestine, colon, rectal, ovarian, breast, cervical and non-small-cell lung cancers. CEA is also expressed by epithelial cells in several non-malignant disorders, including diverticulitis, pancreatitis, inflammatory bowel disease, cirrhosis, hepatitis, bronchitis and renal failure and also in heavy smokers.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA150Hu01 Recombinant Carcinoembryonic Antigen (CEA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA150Hu02 Recombinant Carcinoembryonic Antigen (CEA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA150Hu03 Recombinant Carcinoembryonic Antigen (CEA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA150Hu04 Recombinant Carcinoembryonic Antigen (CEA) Positive Control; Immunogen; SDS-PAGE; WB.
APA150Hu61 Active Carcinoembryonic Antigen (CEA) Cell culture; Activity Assays.
EPA150Hu61 Eukaryotic Carcinoembryonic Antigen (CEA) Positive Control; Immunogen; SDS-PAGE; WB.
APA150Hu04 Active Carcinoembryonic Antigen (CEA) Cell culture; Activity Assays.
Antibodies PAA150Hu01 Polyclonal Antibody to Carcinoembryonic Antigen (CEA) WB; IHC; ICC; IP.
MAA150Hu22 Monoclonal Antibody to Carcinoembryonic Antigen (CEA) WB; IHC; ICC; IP.
PAA150Hu02 Polyclonal Antibody to Carcinoembryonic Antigen (CEA) WB; IHC; ICC; IP.
LAA150Hu71 Biotin-Linked Polyclonal Antibody to Carcinoembryonic Antigen (CEA) WB; IHC; ICC.
PAA150Hu04 Polyclonal Antibody to Carcinoembryonic Antigen (CEA) WB; IHC; ICC; IP.
PAA150Hu03 Polyclonal Antibody to Carcinoembryonic Antigen (CEA) WB; IHC; ICC; IP.
Assay Kits SEA150Hu ELISA Kit for Carcinoembryonic Antigen (CEA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA150Mu01 Recombinant Carcinoembryonic Antigen (CEA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA150Mu02 Recombinant Carcinoembryonic Antigen (CEA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA150Mu01 Polyclonal Antibody to Carcinoembryonic Antigen (CEA) WB; IHC; ICC; IP.
PAA150Mu02 Polyclonal Antibody to Carcinoembryonic Antigen (CEA) WB; IHC; ICC; IP.
LAA150Mu71 Biotin-Linked Polyclonal Antibody to Carcinoembryonic Antigen (CEA) WB; IHC; ICC.
Assay Kits SEA150Mu ELISA Kit for Carcinoembryonic Antigen (CEA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA150Ra01 Recombinant Carcinoembryonic Antigen (CEA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA150Ra01 Polyclonal Antibody to Carcinoembryonic Antigen (CEA) WB; IHC; ICC; IP.
MAA150Ra21 Monoclonal Antibody to Carcinoembryonic Antigen (CEA) WB; IHC; ICC; IP.
Assay Kits SEA150Ra ELISA Kit for Carcinoembryonic Antigen (CEA) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen."Mol. Cell. Biol. 7:3221-3230(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains."Genomics 3:59-66(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression."Mol. Cell. Biol. 10:2738-2748(1990) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence."Biochem. Biophys. Res. Commun. 142:511-518(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure."Proc. Natl. Acad. Sci. U.S.A. 84:2960-2964(1987) [PubMed] [Europe PMC] [Abstract]
  7. "Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion."J. Biol. Chem. 275:26935-26943(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23."FEBS Lett. 475:11-16(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation."Mol. Microbiol. 67:420-434(2008) [PubMed] [Europe PMC] [Abstract]