Stem Cell Factor Receptor (SCFR)


CD117; KIT; C-Kit; PBT; p145 c-Kit; C-Kit Receptor; Tyrosine-Protein Kinase; V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog; Piebald Trait

Stem Cell Factor Receptor (SCFR)

Stem cell factor Receptor(SCFR;CD117), also called KIT or C-kit receptor, is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. This receptor binds to stem cell factor (a substance that causes certain types of cells to grow). Altered forms of this receptor may be associated with some types of cancer.C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in its encoded gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

Proteins RPA121Hu01 Recombinant Stem Cell Factor Receptor (SCFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA121Hu01 Polyclonal Antibody to Stem Cell Factor Receptor (SCFR) WB; IHC; ICC; IP.
MAA121Hu22 Monoclonal Antibody to Stem Cell Factor Receptor (SCFR) WB; IHC; ICC; IP.
Assay Kits SEA121Hu ELISA Kit for Stem Cell Factor Receptor (SCFR) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA121Hu CLIA Kit for Stem Cell Factor Receptor (SCFR) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

Proteins RPA121Mu01 Recombinant Stem Cell Factor Receptor (SCFR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA121Mu02 Recombinant Stem Cell Factor Receptor (SCFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA121Mu01 Polyclonal Antibody to Stem Cell Factor Receptor (SCFR) WB; IHC; ICC; IP.
PAA121Mu02 Polyclonal Antibody to Stem Cell Factor Receptor (SCFR) WB; IHC; ICC; IP.
Assay Kits SEA121Mu ELISA Kit for Stem Cell Factor Receptor (SCFR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

Proteins n/a Recombinant Stem Cell Factor Receptor (SCFR) Recombinant Protein Customized Service Offer
Antibodies MAA121Ra21 Monoclonal Antibody to Stem Cell Factor Receptor (SCFR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Stem Cell Factor Receptor (SCFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stem Cell Factor Receptor (SCFR) ELISA Kit Customized Service Offer
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  52. "Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors."Science 279:577-580(1998) [PubMed] [Europe PMC] [Abstract]
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  55. "Three novel mutations of the proto-oncogene KIT cause human piebaldism."Am. J. Med. Genet. 95:79-81(2000) [PubMed] [Europe PMC] [Abstract]
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