Cluster Of Differentiation 40 Ligand (CD40L)

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CD154; TRAP; HIGM1; IGM; IMD3; TBAM; T-BAM; TNFSF5; Gp39; TNF Superfamily Member 5; Hyper-IgM Syndrome; TNF-Related Activation Protein; T-Cell B-Cell Activating Molecule

Cluster Of Differentiation 40 Ligand (CD40L)

 is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40L plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3.

CD40L is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA119Hu01 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
RPA119Hu02 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
RPA119Hu03 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA119Hu01 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
MAA119Hu22 Monoclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
PAA119Hu02 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
LAA119Hu71 Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC.
LAA119Hu81 FITC-Linked Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IF.
MAA119Hu21 Monoclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
PAA119Hu03 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
Assay Kits SEA119Hu ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA119Mu01 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
RPA119Mu02 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA119Mu01 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
PAA119Mu02 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
Assay Kits SEA119Mu ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA119Ra01 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA119Ra01 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
MAA119Ra21 Monoclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
Assay Kits SEA119Ra ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) Polyclonal Antibody Customized Service Offer
Assay Kits SEA119Rb ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA119Si01 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA119Si01 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 40 Ligand (CD40L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA119Ca01 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA119Ca01 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
MAA119Ca21 Monoclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
Assay Kits SEA119Ca ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA119Po01 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
RPA119Po02 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
RPA119Po03 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA119Po01 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
PAA119Po02 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
PAA119Po03 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
Assay Kits SEA119Po ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA119Bo01 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA119Bo01 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
LAA119Bo81 FITC-Linked Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IF.
LAA119Bo71 Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 40 Ligand (CD40L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA119Ga01 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA119Ga01 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 40 Ligand (CD40L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) ELISA Kit Customized Service Offer

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA119Fi01 Recombinant Cluster Of Differentiation 40 Ligand (CD40L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA119Fi01 Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 40 Ligand (CD40L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) ELISA Kit Customized Service Offer
  1. "Cloning of TRAP, a ligand for CD40 on human T cells."Eur. J. Immunol. 22:3191-3194(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity."EMBO J. 11:4313-4321(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome."Cell 72:291-300(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion."J. Exp. Med. 176:1543-1550(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production."FEBS Lett. 315:259-266(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Structural organization of the gene for CD40 ligand: molecular analysis for diagnosis of X-linked hyper-IgM syndrome."Biochim. Biophys. Acta 1260:67-72(1995) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human native soluble CD40L is a biologically active trimer, processed inside microsomes."J. Biol. Chem. 271:5965-5967(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells."Protein Expr. Purif. 23:301-310(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization."J. Am. Coll. Cardiol. 43:2319-2325(2004) [PubMed] [Europe PMC] [Abstract]
  11. "2-A crystal structure of an extracellular fragment of human CD40 ligand."Structure 3:1031-1039(1995) [PubMed] [Europe PMC] [Abstract]
  12. "The role of polar interactions in the molecular recognition of CD40L with its receptor CD40."Protein Sci. 7:1124-1135(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM."Nature 361:539-541(1993) [PubMed] [Europe PMC] [Abstract]
  14. "CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM."Nature 361:541-543(1993) [PubMed] [Europe PMC] [Abstract]
  15. "CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome."Science 259:990-993(1993) [PubMed] [Europe PMC] [Abstract]
  16. "Characterization of nine novel mutations in the CD40 ligand gene in patients with X-linked hyper IgM syndrome of various ancestry."Am. J. Hum. Genet. 56:898-906(1995) [PubMed] [Europe PMC] [Abstract]
  17. "Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM."J. Clin. Invest. 95:510-514(1995) [PubMed] [Europe PMC] [Abstract]
  18. "Mutation analysis in CD40 ligand deficiency leading to X-linked hypogammaglobulinemia with hyper IgM syndrome."Hum. Mutat. 8:223-228(1996) [PubMed] [Europe PMC] [Abstract]
  19. "A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome."J. Clin. Invest. 97:196-201(1996) [PubMed] [Europe PMC] [Abstract]
  20. "Mutations of the CD40 ligand gene in 13 Japanese patients with X-linked hyper-IgM syndrome."Hum. Genet. 99:624-627(1997) [PubMed] [Europe PMC] [Abstract]
  21. "Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome."Blood 92:2421-2434(1998) [PubMed] [Europe PMC] [Abstract]