Meningioma Expressed Antigen 5 (MGEA5)

[Edit]

NAGase; MEA5; NCOAT; Hexosaminidase C; N-Acetylhexosaminidase; Hyaluronidase; Meningioma-Expressed Antigen 5; Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase

Meningioma Expressed Antigen 5 (MGEA5)

N-Acetyl-β-D-glucosaminidase (abbreviated to as NAGase) is an enzyme in lysosome which is contained abundantly in the renal tubular epithelia and is related to the degradation of mucopolysaccharides and glycoproteins.

It is recognized that the NAGase in urine increases in various cases of renal diseases or after an operation of the kidney and the NAGase in urine as well as serum increases in case of diabetes. In the field of clinical and animal experiments, the measurement of the NAGase has attracted an interest in connection with diagnosis of various renal diseases and also as an indicator in examining nephrotoxicity. In the prior art, p-nitrophenyl N-acetyl-β-D-glucosaminide and 4-methylumbelliferyl-N-acetyl-β- D-glucosaminide have generally been used in the determination of the NAGase activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA069Hu01 Recombinant Meningioma Expressed Antigen 5 (MGEA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA069Hu02 Recombinant Meningioma Expressed Antigen 5 (MGEA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA069Hu03 Recombinant Meningioma Expressed Antigen 5 (MGEA5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA069Hu01 Polyclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB,IHC,ICC/IF
MAA069Hu22 Monoclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB; IHC; ICC; IP.
PAA069Hu02 Polyclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB; IHC; ICC; IP.
LAA069Hu71 Biotin-Linked Polyclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB; IHC; ICC.
PAA069Hu03 Polyclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB; IHC; ICC; IP.
Assay Kits SEA069Hu ELISA Kit for Meningioma Expressed Antigen 5 (MGEA5) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA069Hu CLIA Kit for Meningioma Expressed Antigen 5 (MGEA5) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA069Mu01 Recombinant Meningioma Expressed Antigen 5 (MGEA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA069Mu02 Recombinant Meningioma Expressed Antigen 5 (MGEA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA069Mu03 Recombinant Meningioma Expressed Antigen 5 (MGEA5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA069Mu01 Polyclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB; IHC; ICC; IP.
PAA069Mu02 Polyclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB; IHC; ICC; IP.
LAA069Mu71 Biotin-Linked Polyclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB; IHC; ICC.
PAA069Mu03 Polyclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB; IHC; ICC; IP.
Assay Kits SEA069Mu ELISA Kit for Meningioma Expressed Antigen 5 (MGEA5) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA069Mu CLIA Kit for Meningioma Expressed Antigen 5 (MGEA5) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA069Ra01 Recombinant Meningioma Expressed Antigen 5 (MGEA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA069Ra02 Recombinant Meningioma Expressed Antigen 5 (MGEA5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA069Ra01 Polyclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB; IHC; ICC; IP.
PAA069Ra02 Polyclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB; IHC; ICC; IP.
LAA069Ra71 Biotin-Linked Polyclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB; IHC; ICC.
Assay Kits SEA069Ra ELISA Kit for Meningioma Expressed Antigen 5 (MGEA5) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA069Ra CLIA Kit for Meningioma Expressed Antigen 5 (MGEA5) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Meningioma Expressed Antigen 5 (MGEA5) Recombinant Protein Customized Service Offer
Antibodies PAA069Bo01 Polyclonal Antibody to Meningioma Expressed Antigen 5 (MGEA5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Meningioma Expressed Antigen 5 (MGEA5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Meningioma Expressed Antigen 5 (MGEA5) ELISA Kit Customized Service Offer
  1. "Novel immunogenic antigen homologous to hyaluronidase in meningioma."Hum. Mol. Genet. 7:1859-1872(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase."Biochem. Biophys. Res. Commun. 283:634-640(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain."J. Biol. Chem. 276:9838-9845(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase."J. Biol. Chem. 277:1755-1761(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants."Biochemistry 45:3835-3844(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of beta-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis."J. Biol. Chem. 283:23557-23566(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Human OGA binds substrates in a conserved peptide recognition groove."Biochem. J. 432:1-7(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Isoforms of human O-GlcNAcase show distinct catalytic efficiencies."Biochemistry (Mosc.) 75:938-943(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain."Open Biol. 3:130021-130021(2013) [PubMed] [Europe PMC] [Abstract]
  21. "Synergy of peptide and sugar in O-GlcNAcase substrate recognition."Chem. Biol. 19:173-178(2012) [PubMed] [Europe PMC] [Abstract]