Colony Stimulating Factor 3, Granulocyte (GCSF)

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CSF3; G-CSF; Granulocyte Colony Stimulating Factor; Pluripoietin; Filgrastim; Lenograstim

Colony Stimulating Factor 3, Granulocyte (GCSF)

G-CSF is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. It is produced by activated monocytes/macrophages, fibroblasts, endothelial cells, astrocytes, osteoblasts and bone marrow stromal cells. In addition, various carcinoma cell lines and myeloblastic leukemia cells can produce G-CSF constitutively. G-CSF and G-CSF receptors have also been shown to be produced by placental, decidual and endometrial gland cells during pregnancy, suggesting that G-CSF may play a role in decidual and placental functions. Clinical use of G-CSF has been approved for the amelioration of chemotherapy-induced neutropenia as well as for severe chronic neutropenia following bone marrow transplants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA042Hu01 Recombinant Colony Stimulating Factor 3, Granulocyte (GCSF) Positive Control; Immunogen; SDS-PAGE; WB.
APA042Hu01 Active Colony Stimulating Factor 3, Granulocyte (GCSF) Cell culture; Activity Assays.
Antibodies PAA042Hu01 Polyclonal Antibody to Colony Stimulating Factor 3, Granulocyte (GCSF) WB; IHC; ICC; IP.
MAA042Hu22 Monoclonal Antibody to Colony Stimulating Factor 3, Granulocyte (GCSF) WB; IHC; ICC; IP.
Assay Kits SEA042Hu ELISA Kit for Colony Stimulating Factor 3, Granulocyte (GCSF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA042Hu CLIA Kit for Colony Stimulating Factor 3, Granulocyte (GCSF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA042Mu01 Recombinant Colony Stimulating Factor 3, Granulocyte (GCSF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA042Mu02 Recombinant Colony Stimulating Factor 3, Granulocyte (GCSF) Positive Control; Immunogen; SDS-PAGE; WB.
APA042Mu01 Active Colony Stimulating Factor 3, Granulocyte (GCSF) Cell culture; Activity Assays.
Antibodies PAA042Mu01 Polyclonal Antibody to Colony Stimulating Factor 3, Granulocyte (GCSF) WB; IHC; ICC; IP.
PAA042Mu02 Polyclonal Antibody to Colony Stimulating Factor 3, Granulocyte (GCSF) WB; IHC; ICC; IP.
Assay Kits SEA042Mu ELISA Kit for Colony Stimulating Factor 3, Granulocyte (GCSF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA042Mu CLIA Kit for Colony Stimulating Factor 3, Granulocyte (GCSF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA042Ra01 Recombinant Colony Stimulating Factor 3, Granulocyte (GCSF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA042Ra01 Polyclonal Antibody to Colony Stimulating Factor 3, Granulocyte (GCSF) WB; IHC; ICC; IP.
MAA042Ra21 Monoclonal Antibody to Colony Stimulating Factor 3, Granulocyte (GCSF) WB; IHC; ICC; IP.
Assay Kits SEA042Ra ELISA Kit for Colony Stimulating Factor 3, Granulocyte (GCSF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA042Ra CLIA Kit for Colony Stimulating Factor 3, Granulocyte (GCSF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA042Po01 Recombinant Colony Stimulating Factor 3, Granulocyte (GCSF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA042Po01 Polyclonal Antibody to Colony Stimulating Factor 3, Granulocyte (GCSF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Colony Stimulating Factor 3, Granulocyte (GCSF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Colony Stimulating Factor 3, Granulocyte (GCSF) ELISA Kit Customized Service Offer
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  2. "The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor."EMBO J. 5:575-581(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Expression of granulocyte colony-stimulating factor by human cell lines."J. Leukoc. Biol. 41:302-306(1987) [PubMed] [Europe PMC] [Abstract]
  4. "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes."Genomics 83:566-571(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells."Science 232:61-66(1986) [PubMed] [Europe PMC] [Abstract]
  7. "Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region."Arch. Biochem. Biophys. 324:344-356(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Glycosidase digestion, electrophoresis and chromatographic analysis of recombinant human granulocyte colony-stimulating factor glycoforms produced in Chinese hamster ovary cells."J. Chromatogr. A 637:55-62(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Secondary structure of human granulocyte colony-stimulating factor derived from NMR spectroscopy."FEBS Lett. 314:435-439(1992) [PubMed] [Europe PMC] [Abstract]
  10. "Structure and dynamics of the human granulocyte colony-stimulating factor determined by NMR spectroscopy. Loop mobility in a four-helix-bundle protein."Biochemistry 33:8453-8463(1994) [PubMed] [Europe PMC] [Abstract]
  11. "The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors."Proc. Natl. Acad. Sci. U.S.A. 90:5167-5171(1993) [PubMed] [Europe PMC] [Abstract]
  12. "Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme."Nature 401:713-717(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex."Proc. Natl. Acad. Sci. U.S.A. 103:3135-3140(2006) [PubMed] [Europe PMC] [Abstract]