Ciliary Neurotrophic Factor (CNTF)

Ciliary neurotrophic factor is a polypeptide hormone and nerve growth factor whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations including astrocytes. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks.

A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. Co-transcription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA021Hu01 Recombinant Ciliary Neurotrophic Factor (CNTF) Positive Control; Immunogen; SDS-PAGE; WB.
APA021Hu01 Active Ciliary Neurotrophic Factor (CNTF) Cell culture; Activity Assays.
Antibodies PAA021Hu01 Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IP.
MAA021Hu22 Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IP.
LAA021Hu71 Biotin-Linked Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC.
Assay Kits SEA021Hu ELISA Kit for Ciliary Neurotrophic Factor (CNTF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA021Hu CLIA Kit for Ciliary Neurotrophic Factor (CNTF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA021Mu01 Recombinant Ciliary Neurotrophic Factor (CNTF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA021Mu02 Recombinant Ciliary Neurotrophic Factor (CNTF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA021Mu01 Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IP.
PAA021Mu02 Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IP.
Assay Kits SEA021Mu ELISA Kit for Ciliary Neurotrophic Factor (CNTF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA021Mu CLIA Kit for Ciliary Neurotrophic Factor (CNTF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA021Ra01 Recombinant Ciliary Neurotrophic Factor (CNTF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA021Ra01 Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IP.
LAA021Ra71 Biotin-Linked Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC.
LAA021Ra81 FITC-Linked Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IF.
MAA021Ra21 Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IP.
Assay Kits SEA021Ra ELISA Kit for Ciliary Neurotrophic Factor (CNTF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA021Ra CLIA Kit for Ciliary Neurotrophic Factor (CNTF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA021Rb01 Recombinant Ciliary Neurotrophic Factor (CNTF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA021Rb51 Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IP.
MAA021Rb21 Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IP.
Assay Kits SEA021Rb ELISA Kit for Ciliary Neurotrophic Factor (CNTF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA021Rb CLIA Kit for Ciliary Neurotrophic Factor (CNTF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA021Po01 Recombinant Ciliary Neurotrophic Factor (CNTF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA021Po01 Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IP.
MAA021Po21 Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IP.
Assay Kits SEA021Po ELISA Kit for Ciliary Neurotrophic Factor (CNTF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA021Po CLIA Kit for Ciliary Neurotrophic Factor (CNTF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA021Ga01 Recombinant Ciliary Neurotrophic Factor (CNTF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA021Ga01 Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IP.
MAA021Ga21 Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) WB; IHC; ICC; IP.
Assay Kits SEA021Ga ELISA Kit for Ciliary Neurotrophic Factor (CNTF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA021Ga CLIA Kit for Ciliary Neurotrophic Factor (CNTF) Chemiluminescent immunoassay for Antigen Detection.
  1. "Recombinant human and rat ciliary neurotrophic factors."J. Neurochem. 57:1003-1012(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of human ciliary neurotrophic factor."Eur. J. Biochem. 201:289-294(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Sequence and structural organization of the human gene encoding ciliary neurotrophic factor."Gene 102:271-276(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli."Biochim. Biophys. Acta 1090:70-80(1991) [PubMed] [Europe PMC] [Abstract]
  5. "A null mutation in the human CNTF gene is not causally related to neurological diseases."Nat. Genet. 7:79-84(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing."EMBO J. 14:2689-2699(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  10. ErratumNat. Genet. 23:373-373(1999)