Angiopoietin 2 (ANGPT2)

Angiopoietin-2 (Ang-2) is a secreted glycoprotein that plays a complex role in vascular development. Ang-2 contains an N-terminal coiled-coildomain, 58 - 254 amino acids (aa) and a C-terminal fibrinogen-like domain, 281 - 467 aa, that is also found in other proteins including fibrinogen, tenascin, and ficolin. Located at the N-terminus are stretches of hydrophobic residues typical of secretory signal sequences. While Ang-2 is widely expressed in the mouse embryo, it is restricted postnatally to pro-angiogenic regions including the placenta, ovaries, and uterus. Ang-2 has been implicated in cancer development due to its role in angiogenesis.Ang-2-mediated destabilization of mature vessel structures accompanied by the presence of VEGF, may contribute to the angiogenesis associated with tumor tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA009Hu01 Recombinant Angiopoietin 2 (ANGPT2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA009Hu02 Recombinant Angiopoietin 2 (ANGPT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA009Hu01 Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
MAA009Hu22 Monoclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
PAA009Hu02 Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
LAA009Hu71 Biotin-Linked Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC.
Assay Kits SEA009Hu ELISA Kit for Angiopoietin 2 (ANGPT2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA009Hu CLIA Kit for Angiopoietin 2 (ANGPT2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA009Mu01 Recombinant Angiopoietin 2 (ANGPT2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA009Mu02 Recombinant Angiopoietin 2 (ANGPT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA009Mu01 Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
LAA009Mu71 Biotin-Linked Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC.
LAA009Mu81 FITC-Linked Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IF.
PAA009Mu02 Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
Assay Kits SEA009Mu ELISA Kit for Angiopoietin 2 (ANGPT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA009Ra01 Recombinant Angiopoietin 2 (ANGPT2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA009Ra02 Recombinant Angiopoietin 2 (ANGPT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA009Ra01 Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
PAA009Ra02 Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
LAA009Ra71 Biotin-Linked Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC.
Assay Kits SEA009Ra ELISA Kit for Angiopoietin 2 (ANGPT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA009Gu01 Recombinant Angiopoietin 2 (ANGPT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA009Gu01 Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Angiopoietin 2 (ANGPT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiopoietin 2 (ANGPT2) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA009Rb01 Recombinant Angiopoietin 2 (ANGPT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA009Rb51 Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
MAA009Rb21 Monoclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
Assay Kits SEA009Rb ELISA Kit for Angiopoietin 2 (ANGPT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA009Po01 Recombinant Angiopoietin 2 (ANGPT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA009Po01 Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
MAA009Po21 Monoclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
Assay Kits SEA009Po ELISA Kit for Angiopoietin 2 (ANGPT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA009Bo01 Recombinant Angiopoietin 2 (ANGPT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA009Bo01 Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Angiopoietin 2 (ANGPT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiopoietin 2 (ANGPT2) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA009Ga01 Recombinant Angiopoietin 2 (ANGPT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA009Ga01 Polyclonal Antibody to Angiopoietin 2 (ANGPT2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Angiopoietin 2 (ANGPT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiopoietin 2 (ANGPT2) ELISA Kit Customized Service Offer
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  2. "Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma."J. Clin. Invest. 103:341-345(1999) [PubMed] [Europe PMC] [Abstract]
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  7. "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats."J. Biol. Chem. 278:1721-1727(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Biological characterization of angiopoietin-3 and angiopoietin-4."FASEB J. 18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells."Angiogenesis 12:25-33(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium."Mol. Cell. Biol. 29:2011-2022(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system."Nat. Rev. Mol. Cell Biol. 10:165-177(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition."Structure 13:825-832(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex."Nat. Struct. Mol. Biol. 13:524-532(2006) [PubMed] [Europe PMC] [Abstract]