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Recombinant Cathepsin D (CTSD)

CPSD; CLN10; Lysosomal Aspartyl Protease; Ceroid-Lipofuscinosis,Neuronal 10

  • Product No.RPB280Hu01
  • Organism SpeciesHomo sapiens (Human) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationMembrane
  • Predicted Molecular Mass16.5kDa
  • Accurate Molecular Mass17kDa(Analysis of differences refer to the manual)
  • Residues & TagsArg23~Gln161 with N-terminal His Tag
  • Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder
  • Purity> 95%
  • Isoelectric Point6.6
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 232  US$ 580  US$ 1160  US$ 3480  US$ 8700 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Molecular Immunology Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro ScienceDirect: S0161589011008297
21 Plasma Cathepsin D Levels: A Novel Tool to Predict Pediatric Hepatic Inflammation PubMed: 25732418
Scientific Reportes Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention pubmed:27922112
Biomedicine & pharmacotherapy Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms pubmed:28061403
JGH OPEN Limited applicability of cathepsin D for the diagnosis and monitoring of non‐alcoholic steatohepatitis
Diabetologia Plasma cathepsin D activity is negatively associated with hepatic insulin sensitivity in overweight and obese humans Pubmed: 31690989
Antioxidants Iron and Advanced Glycation End Products: Emerging Role of Iron in Androgen Deficiency in Obesity Pubmed: 32235809
Peptides LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders 33253777
Cells Identification of Cathepsin D as a Plasma Biomarker for Alzheimer's Disease 33445607
J Chem Neuroanat Analysis of silymarin-modulating effects against acrylamide-induced cerebellar damage in male rats: Biochemical and pathological markers 33965515
Front Cell Infect Microbiol PGRS Domain of Rv0297 of Mycobacterium tuberculosis Is Involved in Modulation of Macrophage Functions to Favor Bacterial Persistence 33042856
Nutr Metab Cardiovasc Dis Serum CathepsinD in pregnancy: relation with metabolic and inflammatory markers and effects of fish oils and probiotics Pubmed:35304048
Biosensors A Comparison of Various Chips Used for the Manufacture of Biosensors Applied in Non-Fluidic Array SPRi, Based on the Example of Determination of Cathepsin D Pubmed:35049649
Catalog No. Related products for research use of Homo sapiens (Human) Organism species Applications (RESEARCH USE ONLY!)
APB280Hu61 Active Cathepsin D (CTSD) Cell culture; Activity Assays.
EPB280Hu61 Eukaryotic Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Hu01 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
EPB280Hu62 Eukaryotic Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Hu02 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Hu03 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB280Hu04 Recombinant Cathepsin D (CTSD) Positive Control; Immunogen; SDS-PAGE; WB.
PAB280Hu02 Polyclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
PAB280Hu01 Polyclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
LAB280Hu71 Biotin-Linked Polyclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC.
MAB280Hu21 Monoclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
MAB280Hu26 Monoclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
MAB280Hu22 Monoclonal Antibody to Cathepsin D (CTSD) WB; IHC; ICC; IP.
FAB280Hu02 Anti-Cathepsin D (CTSD) Monoclonal Antibody Flow cytometry.
SEB280Hu ELISA Kit for Cathepsin D (CTSD) Enzyme-linked immunosorbent assay for Antigen Detection.
HEB280Hu High Sensitive ELISA Kit for Cathepsin D (CTSD) Enzyme-linked immunosorbent assay for Antigen Detection.
LMB280Hu Multiplex Assay Kit for Cathepsin D (CTSD) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.