Monoclonal Antibody to N-Terminal Pro-Brain Natriuretic Peptide (NT-ProBNP)



The antibody is a mouse monoclonal antibody raised against NT-ProBNP. It has been selected for its ability to recognize NT-ProBNP in immunohistochemical staining and western blotting.


Western blotting: 0.5-3µg/mL;
Immunohistochemistry: 5-30µg/mL;
Immunocytochemistry: 5-30µg/mL;
Optimal working dilutions must be determined by end user.


Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.


The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.



Magazine Citations
Eur Rev Med Pharmacol Sci. The role of serum n-terminal pro-brain natriuretic peptide in transient tachypnea of the newborn Europeanreview: Source
Transplantation Proceedings Vascular Adhesion Protein-1, a Novel Molecule, in Kidney and Heart Allograft Recipients Pubmed: 23769096
34 Paradoxical low-flow, low-gradient aortic stenosis despite preserved left ventricular ejection fraction: new insights from weights of operatively excised aortic valves Pubmed: 24755006
Integrative Medicine Insights A Randomized Controlled Trial to Study the Effect of Yoga Therapy on Cardiac Function and N Terminal Pro BNP in Heart Failure NCBI: PMC3981569
Liver Int.? Diabetes enhances the intrahepatic vascular response to endothelin-1 in cirrhotic rats: association with the ETA receptor and pERK up-regulation. Pubmed:24636620
Eur J Heart Fail. Growth-differentiation factor 15 and osteoprotegerin in acute myocardial infarction complicated by cardiogenic shock: a biomarker substudy of the IABP-SHOCK II-trial. Pubmed:24903195
Scientific Reports Biomarkers and Echocardiographic Predictors of Myocardial Dysfunction in Patients with Hypertension PubMed: 25747153
Int J Mol Sci The Multi-Biomarker Approach for Heart Failure in Patients with Hypertension PubMed: 25984599
scientific reports Effect of Treatment on Body Fluid in Patients with Unilateral Aldosterone Producing Adenoma: Adrenalectomy versus Spironolactone PubMed: 26477337
Liver Int Diabetes enhances the intrahepatic vascular response to endothelin‐1 in cirrhotic rats: association with the ETA receptor and pERK up‐regulation PubMed: 24636620
Int J Clin Exp Pathol Qiliqiangxin improves cardiac function and attenuates cardiac remodeling in rats with experimental myocardial infarction PubMed: 26261541
Iranian Journal of Pediatrics NT-proBNP in Children With Left to Right Shunt and Dilated Cardiomyopathy serve:4485
International Journal of Cardiology Human myoblast transplantation in mice infarcted heart alters the expression profile of cardiac genes associated with left ventricle remodeling Pubmed:26457413
IJC Heart & Vasculature Cardiovascular changes in patients with non-severe Plasmodium vivax malaria article:S2352-9067(16)30010-0
Heart Lung Circ Soluble Glycoprotein 130 and Heat Shock Protein 27 as Novel Candidate Biomarkers of Chronic Heart Failure with Preserved Ejection Fraction Pubmed:27067668
International journal of cardiology Differences in biochemical and genetic biomarkers in patients with heart failure of various etiologies. pubmed:27448535
Experimental and Therapeutic Medicine Expression of pericardial fluid T-cells and related inflammatory cytokines in patients with chronic heart failure. pubmed:28565777
Journal of Cardiovascular Electrophysiology Effect of Cardiac Resynchronization Therapy on Myocardial Fibrosis and Relevant Cytokines in a Canine Model With Experimental Heart Failure. pubmed:28127817
Journal of Cardiovascular Ecography Study of Vitamin D Status in Patients with Dilated Cardiomyopathy at a Teaching Hospital in North India. pubmed:28465969
International Journal of Cardiology 5-methoxytryptophan is a potential marker for post-myocardial infarction heart failure - apreliminary approach to clinical utility. pubmed:27526355
Cardiovasc Toxicol Beneficial Effects of Ozone Therapy on Oxidative Stress, Cardiac Functions and Clinical Findings in Patients with Heart Failure Reduced Ejection Fraction pubmed:28097518
Sci Rep.  Serial heart rhythm complexity changes in patients with anterior wall ST segment elevation myocardial infarction. pubmed:28252107
Journal of Cardiovascular Magnetic Resonance The predictive capabilities of a novel cardiovascular magnetic resonance derived marker of cardiopulmonary reserve on established prognostic surrogate markers in patients with pulmonary vascular disease: results of a longitudinal pilot study pubmed:28065166
Archivos de medicina veterinaria Cardiac biomarkers in dogs with visceral leishmaniasis S0301-732X2016000300004
Original article Evaluation of N-Terminal Pro Brain Natriuretic Peptide as a biomarker for clinical severity of heart failure in pediatric population Attach432
Evidence-Based Complementary and Alternative Medicine Cardioprotection against Heart Failure by Shenfu Injection via TGF-β/Smads Signaling Pathway pubmed:28698735
Scientific Reports QSKL protects against myocardial apoptosis on heart failure via PI3K/Akt-p53 signaling pathway. pubmed:29209026
Vascular Pharmacology Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats pubmed:29100963
Evidence-based complementary and alternative medicine Qiliqiangxin Enhances Cardiac Glucose Metabolism and Improves Diastolic Function in Spontaneously Hypertensive Rats pubmed:28706558
Europace Prediction of electro-anatomical substrate using APPLE score and biomarkers Pubmed:29893827
Heart Rhythm Role of NT-proANP and NT-proBNP in patients with atrial fibrillation: Association with atrial fibrillation progression phenotypes Pubmed:29604419
American Journal of Hypertension MicroRNAs in Peripheral Mononuclear Cells as Potential Biomarkers in Hypertensive Patients With Heart Failure With Preserved Ejection Fraction Pubmed:29506053
International Journal of Molecular Medicine Differential microRNA expression profiles and bioinformatics analysis between young and aging spontaneously hypertensive rats Pubmed:29328372
Biomarkers Regulation of circulating chromogranin B levels in heart failure Pubmed:29098879
Lung Effect of 6-min Walk Test on pro-BNP Levels in Patients with Pulmonary Arterial Hypertension Pubmed:29564533
International Journal of Clinical and Exp Medicine Dynamic monitoring the level of NT-proBNP in assessing the value of cardiac function and prognosis in patients with systemic infection ijcem0072283.pdf
FASEB Journal Signature-oriented investigation of the efficacy of multicomponent drugs against heart failure Pubmed: 30230922
International Journal of Clinical and Experimental Medicine Qiliqiangxin ameliorates cardiac dysfunction in heart failure rats post myocardial infarction via activation of HIF/VEGF pathway
Pediatric Hematology Oncology Journal Decreasing cardiac iron overload with Amlodipine and Spirulina in children with β-thalassemia Doi: 10.1016/j.phoj.2018.10.001
Journal of Clinical Medicine Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon Pubmed: 30625976
Van Veterinary Journal Relationship between Natriuretic Peptide Levels with Heart and Kidney Parameters in Rats with Chronic Renal Failure.
Journal of Complementary and Integrative Medicine Biological markers for the effects of yoga as a complementary and alternative medicine Pubmed: 30735481
Frontiers in Pharmacology Trimetazidine Attenuates Exhaustive Exercise-Induced Myocardial Injury in Rats via Regulation of the Nrf2/NF-κB Signaling Pathway Pubmed: 30890937
Journal of Clinical Medicine Potential Effects of CXCL9 and CCL20 on Cardiac Fibrosis in Patients with Myocardial Infarction and Isoproterenol-Treated Rats Pubmed: 31083544
PLoS One Evaluation of heart rate variability and behavior of electrocardiographic parameters in dogs affected by chronic Monocytic Ehrlichiosis Pubmed: 31125348
Cardiovascular Research Cardio-protective effect of the secretome of Sca-1+ and Sca-1-cells in heart failure–not equal, but equally important? Paracrine cell effects on heart failure
Advances in Medical Sciences The potential role of inflammation in cryptogenic stroke
Disease Markers Arterial Stiffness and Indices of Left Ventricular Diastolic Dysfunction in Patients with Embolic Stroke of Undetermined Etiology Pubmed: 31612072
Journal of Human Kinetics Hormonal Response to Incremental and Continuous Exercise in Cyclists with Left Ventricle Hypertrophy Pubmed: 32148580
Nature Communications Preclinical development of a miR-132 inhibitor for heart failure treatment Pubmed: 32005803
MEDIATORS OF INFLAMMATION Evaluating the Relationship of GDF-15 with Clinical Characteristics, Cardinal Features, and Survival in Multiple Myeloma Pubmed: 33144847
EUROPEAN HEART JOURNAL CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure Pubmed: 33089304
REPRODUCTIVE TOXICOLOGY Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice Pubmed: 33068716
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Apela improves cardiac and renal function in mice with acute myocardial infarction Pubmed: 32686917
Catalog No. Related products for research use of Homo sapiens (Human), Mus musculus (Mouse), Rattus norvegicus (Rat), Sus scrofa; Porcine (Pig) Organism species Applications (RESEARCH USE ONLY!)
MAA485Mi21 Monoclonal Antibody to N-Terminal Pro-Brain Natriuretic Peptide (NT-ProBNP) WB; IHC; ICC; IP.