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Rat Model for Menopausal Syndrome (MS)

Perimenopausal Syndrome; PS

  • Product No.DSI814Ra01
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • Prototype SpeciesHuman
  • SourceInduced by injection of ethanol into bilateral ovaries
  • Model Animal StrainsSD rats (SPF), female, health, body weight 220g~240g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period4 weeks
  • Modeling Method1. On aseptic conditions, 0.2 ml ethanol was injected into the bilateral ovaries of rats. The changes of serum estradiol and progesterone were observed every week, and the pathological changes of ovary were observed for 4 weeks.
    2. Collect the blood for the orbit of the rats at 1st, 2nd, 3rd and 4th week. After the blood coagulation, the serum was collected by centrifugation, and stored at the -20 degree. ELISA method was used to determine the concentration of E2 and P in serum. The animals were sacrificed and the ovaries were removed and fixed in 10% formalin for routine histopathological examination.
  • ApplicationsDisease Model
  • Downloadn/a
  • UOM Each case
  • FOB US$ 200 
    For more details, please contact local distributors!

Model Evaluation

Pathological Results

Cytokines Level

Statistical Analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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DSI814Ra01 Rat Model for Menopausal Syndrome (MS) Disease Model