Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c)

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Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c)

Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of additional sORFs in the mtDNA. A sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c that regulates insulin sensitivity and metabolic homeostasis. Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to AMPK activation. MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity. These results suggest that mitochondria may actively regulate metabolic homeostasis at the cellular and organismal level via peptides encoded within their genome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins SPX132Hu01 Synthetic Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c) Immunogen; Blocking Peptide.
CPX132Hu21 OVA Conjugated Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c) Immunogen; SDS-PAGE; WB.
CPX132Hu11 BSA Conjugated Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c) Immunogen; SDS-PAGE; WB.
Antibodies PAX132Hu01 Polyclonal Antibody to Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c) IHC; ICC; IP
Assay Kits CEX132Hu ELISA Kit for Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c) Recombinant Protein Customized Service Offer
Antibodies PAX132Mu01 Polyclonal Antibody to Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c) WB; IHC; ICC; IP.
Assay Kits CEX132Mu ELISA Kit for Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c) Polyclonal Antibody Customized Service Offer
Assay Kits CEX132Ra ELISA Kit for Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance."Cell Metab. 21:443-454(2015) [PubMed] [Europe PMC] [Abstract]