Killer Cell Lectin Like Receptor Subfamily I, Member 1 (KLRI1)

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Killer Cell Lectin Like Receptor Subfamily I, Member 1 (KLRI1)
While the extracellular lectin-like domains of KLRI1 and KLRI2 are similar [74% (rat) and 83% (mouse) amino acid identity], they differ intracellularly. KLRI1 has two immunoreceptor tyrosine-based inhibition motifs (ITIMs) in the cytoplasmic domain, suggesting an inhibitory function. KLRI2 has no ITIM, but a positively charged lysine residue in the transmembrane region, suggesting association with activating adapter molecules. Klri1 and Klri2 are localized within the natural killer (NK) cell gene complex on rat chromosome 4 and mouse chromosome 6. By RT-PCR and Northern blot analysis KLRI1 and KLRI2 were selectively expressed by NK cells in both rat and mouse. Epitope-tagged expression constructs of rat KLRI1 and rat KLRI2 induced surface expression of a nondisulphide-linked protein of M(r) 36,000/39,000 and M(r) 34,000, respectively.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Killer Cell Lectin Like Receptor Subfamily I, Member 1 (KLRI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily I, Member 1 (KLRI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily I, Member 1 (KLRI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Killer Cell Lectin Like Receptor Subfamily I, Member 1 (KLRI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Killer Cell Lectin Like Receptor Subfamily I, Member 1 (KLRI1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Killer Cell Lectin Like Receptor Subfamily I, Member 1 (KLRI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily I, Member 1 (KLRI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily I, Member 1 (KLRI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Killer Cell Lectin Like Receptor Subfamily I, Member 1 (KLRI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Killer Cell Lectin Like Receptor Subfamily I, Member 1 (KLRI1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs."Immunogenetics 56:833-839(2005) [PubMed] [Europe PMC] [Abstract].