≡

Carbonyl Reductase 2 (CBR2)

[Edit]

AP27; LCR; Adipocyte protein P27; Adipocyte protein P27; Lung carbonyl reductase; NADPH-dependent carbonyl reductase 2

Carbonyl Reductase 2 (CBR2)
CCC S668
MGI 107200
UniProt P08074
CBR2, Belongs to the short-chain dehydrogenases/reductases (SDR) family. Lung (ciliated cells, non-ciliated bronchiolar cells and type-II alveolar pneumocytes). Low expression in adipose tissue > testis = heart > kidney = spleen > brain = liver.May function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism.
Carbonyl reductases (CREDs) are enzymes useful for enantiomeric resolutions, chemo- and regioselective reductions/oxidations, and synthesis of chiral alcohols from ketones, ketoacids, and ketoesters. They also catalyse the reduction of a number of aldehydes. The CRED catalysed reduction of the carbonyl moiety requires cofactor (NADH or NADPH) regeneration and is carried out with either isopropyl alcohol or with glucose dehydrogenase.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbonyl Reductase 2 (CBR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbonyl Reductase 2 (CBR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbonyl Reductase 2 (CBR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbonyl Reductase 2 (CBR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonyl Reductase 2 (CBR2) ELISA Kit Customized Service Offer
  1. "A growth factor-repressible gene associated with protein kinase C-mediated inhibition of adipocyte differentiation."J. Cell Biol. 107:279-286(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, expression and tissue distribution of mouse tetrameric carbonyl reductase. Identity with an adipocyte 27-kDa protein."Eur. J. Biochem. 228:381-387(1995) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Ultrastructural localization of carbonyl reductase in mouse lung."Histochem. J. 26:311-316(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Switch of coenzyme specificity of mouse lung carbonyl reductase by substitution of threonine 38 with aspartic acid."J. Biol. Chem. 272:2218-2222(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8-A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family."Structure 4:33-45(1996) [PubMed] [Europe PMC] [Abstract]