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Selenoprotein K (SELK)

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Selenoprotein K (SELK)
CCC S592
MGI 1931466
PubMed 22016385
RGD 1303129
UniProt Q9JLJ1
Selenoprotein K (SelK) is a newly identified selenoprotein. selenium incorporation into SelK was dependent on the 3'UTR of SelK mRNA. Sec insertion sequence (SECIS) RNA binding assays demonstrated that human SBP2 bound to the SelK SECIS element through the conserved non-Watson-Crick base pair quartet but not the AAT motif.
Examination of the expression pattern revealed that human SelK mRNA was highly expressed in heart. Immunofluorescence analysis showed that SelK localized to the endoplasmic reticulum. overexpression of SelK attenuated the intracellular reactive oxygen species level and protected cells from oxidative stress-induced toxicity in cardiomyocytes. SelK is a novel antioxidant in cardiomyocytes and is related to the regulation of cellular redox balance.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Selenoprotein K (SELK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Selenoprotein K (SELK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Selenoprotein K (SELK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Selenoprotein K (SELK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Selenoprotein K (SELK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Selenoprotein K (SELK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Selenoprotein K (SELK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Selenoprotein K (SELK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Selenoprotein K (SELK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Selenoprotein K (SELK) ELISA Kit Customized Service Offer
  1. "The transcriptional landscape of the mammalian genome." Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages."J. Biol. Chem. 286:34830-34838(2011) [PubMed] [Europe PMC] [Abstract]
  4. "Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis."J. Biol. Chem. 286:42937-42948(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses."J. Immunol. 186:2127-2137(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis."J. Leukoc. Biol. 93:771-780(2013) [PubMed] [Europe PMC] [Abstract]