UDP Glucuronosyltransferase 1 Family, Polypeptide A2 (UGT1A2)

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Ugt1; Bilirubin-specific UDPGT; UDP-glucuronosyltransferase 1-2

UDP Glucuronosyltransferase 1 Family, Polypeptide A2 (UGT1A2)
In cultured primary hepatocytes UDP-glucuronosyltransferase form 1A2 (UGT1A2) mRNA level is 80 times higher than that found in rat liver.By contrast, NFI-C1 was present in rat liver but disappeared immediately upon cultivation of hepatocytes. Only trace amounts of NFI-B and NFI-X were detectable in rat liver and cultured hepatocytes. NFI-A1 elevated expression of the reporter gene that is under the control of CEREM, while NFI-C1 had an inhibitory effect. Co-expression of a constant amount of NFI-A1 with an increasing amount of NFI-C1 led to a concentration-dependent decrease in the expression of the CEREM-controlled reporter gene mediated by NFI-A1. Activation of UGT1A2 expression by NFI-A1 is suppressed by the coexistence of NFI-C1 in the liver, and culture-associated expression of UGT1A2 is triggered by the rapid disappearance of NFI-C1 in cultured hepatocytes.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UDP Glucuronosyltransferase 1 Family, Polypeptide A2 (UGT1A2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UDP Glucuronosyltransferase 1 Family, Polypeptide A2 (UGT1A2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UDP Glucuronosyltransferase 1 Family, Polypeptide A2 (UGT1A2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UDP Glucuronosyltransferase 1 Family, Polypeptide A2 (UGT1A2) CLIA Kit Customized Service Offer
n/a ELISA Kit for UDP Glucuronosyltransferase 1 Family, Polypeptide A2 (UGT1A2) ELISA Kit Customized Service Offer
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  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]