Stearoyl Coenzyme A Desaturase 2 (SCD2)

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Acyl-CoA desaturase 2; Delta(9)-desaturase 2; Fatty acid desaturase 2

Stearoyl Coenzyme A Desaturase 2 (SCD2)
SCD2 was found to be uniquely and absolutely required for adipogenesis. SCD2 also controls the maintenance of adipocyte-specific gene expression in fully differentiated 3T3-L1 adipocytes, including the expression of SCD1. Despite the high sequence similarity between SCD2 and SCD1, silencing of SCD1 did not down-regulate 3T3-L1 cell differentiation or gene expression. SCD2 mRNA expression was also uniquely elevated 44-fold in adipose tissue upon feeding mice a high fat diet, whereas SCD1 showed little response. The inhibition of adipogenesis caused by SCD2 depletion was associated with a decrease in peroxisome proliferator-activated receptor gamma (PPARgamma) mRNA and protein, whereas in mature adipocytes loss of SCD2 diminished PPARgamma protein levels, with little change in mRNA levels.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Stearoyl Coenzyme A Desaturase 2 (SCD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Stearoyl Coenzyme A Desaturase 2 (SCD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stearoyl Coenzyme A Desaturase 2 (SCD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stearoyl Coenzyme A Desaturase 2 (SCD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stearoyl Coenzyme A Desaturase 2 (SCD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Stearoyl Coenzyme A Desaturase 2 (SCD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Stearoyl Coenzyme A Desaturase 2 (SCD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stearoyl Coenzyme A Desaturase 2 (SCD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stearoyl Coenzyme A Desaturase 2 (SCD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stearoyl Coenzyme A Desaturase 2 (SCD2) ELISA Kit Customized Service Offer
  1. "Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase."J. Biol. Chem. 264:14755-14761(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The transcriptional landscape of the mammalian genome." Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]