Vascular Endothelial Growth Factor E (VEGFE)
[Edit]PP283; Vascular endothelial growth factor homolog Vegf-E
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Both VEGF-A and Orf-virus-encoded bind and activate VEGFR2; however, only VEGF-A binds VEGFR-1. Keratin-14-promoterdriven VEGF-E transgenic mice showed a significant increase in mature blood vessels. However, K14–VEGF-A transgenic mice exhibited severe inflammation and oedema with increased angiogenesis, as well as lymphangiogenesis and lymph vessel dilatation. K14–VEGF-A transgenic mice deficient in VEGFR-1 signalling showed decreases in oedema and inflammation with less recruitment of macrophage-lineage cells, suggesting an involvement of VEGFR-1 in these adverse effects. VEGFE might be more useful than VEGFA for proangiogenic therapy. The VEGFE gene is not present in the human genome, suggesting that a progenitor of the Orf virus may have captured an original VEGFE gene from the genome of an animal, probably an animal other than a mammal, by recombination.
Organism species: Pan-species (General)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Vascular Endothelial Growth Factor E (VEGFE) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Vascular Endothelial Growth Factor E (VEGFE) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Vascular Endothelial Growth Factor E (VEGFE) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Vascular Endothelial Growth Factor E (VEGFE) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Vascular Endothelial Growth Factor E (VEGFE) | ELISA Kit Customized Service Offer |