Ataxin 1 Like Protein (ATXN1L)

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BOAT; Brother Of Ataxin-1

Ataxin 1 Like Protein (ATXN1L)
Ataxin-1 is a neurodegenerative disorder protein whose glutamine-repeat expanded form causes spinocerebellar ataxia type 1 (SCA1) in humans and exerts cytotoxicity in Drosophila and mouse. Brother of ataxin-1 (Boat). Boat and ataxin-1 share a conserved AXH domain, which is essential for both proteins' interactions with the transcriptional corepressor SMRT and its Drosophila homolog, SMRTER. The Boat-ataxin-1 interaction is mediated through multiple regions in both proteins, including a newly identified NBA (N-terminal region of Boat and ataxin-1) domain. Correspondingly, in transgenic SCA1 mouse, Boat expression is greatly reduced in Purkinje cells, the primary targets of SCA1. Boat is an in vivo binding partner of ataxin-1 whose altered expression in Purkinje cells may contribute to their degeneration in SCA1 animals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ataxin 1 Like Protein (ATXN1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ataxin 1 Like Protein (ATXN1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ataxin 1 Like Protein (ATXN1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ataxin 1 Like Protein (ATXN1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ataxin 1 Like Protein (ATXN1L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ataxin 1 Like Protein (ATXN1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ataxin 1 Like Protein (ATXN1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ataxin 1 Like Protein (ATXN1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ataxin 1 Like Protein (ATXN1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ataxin 1 Like Protein (ATXN1L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ataxin 1 Like Protein (ATXN1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ataxin 1 Like Protein (ATXN1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ataxin 1 Like Protein (ATXN1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ataxin 1 Like Protein (ATXN1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ataxin 1 Like Protein (ATXN1L) ELISA Kit Customized Service Offer
  1. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1."EMBO J. 24:3339-3351(2005) [PubMed] [Europe PMC] [Abstract]
  3. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway."EMBO Rep. 12:428-435(2011) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]