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LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1)

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PINCH; PINCH1; Particularly interesting new Cys-His protein 1; Renal carcinoma antigen NY-REN-48

LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1)
CCC P882
HGNC 6616
MGI 1195263
PubMed 18436335
RGD 1560732
UniProt P48059
Wiki LIMS1
LIMS1 is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.While ILK depletion reduced AKT phosphorylation on ser473, PINCH1 depletion reduced AKT phosphorylation on both ser473 and thr308. PINCH1 also regulated ILK protein levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP882Hu01 Recombinant LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP882Hu01 Polyclonal Antibody to LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) WB; IHC; ICC; IP.
MAP882Hu21 Monoclonal Antibody to LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) WB; IHC; ICC; IP.
Assay Kits SEP882Hu ELISA Kit for LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) ELISA Kit Customized Service Offer
  1. "A new LIM protein containing an autoepitope homologous to 'senescent cell antigen'."Biochem. Biophys. Res. Commun. 201:1124-1131(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways."Mol. Biol. Cell 9:3367-3382(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
  8. "The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells."Mol. Cell. Biol. 19:2425-2434(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain."J. Biol. Chem. 276:4932-4939(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling."Nat. Struct. Biol. 10:558-564(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of the second and third LIM domain of particularly interesting new Cys-His protein (PINCH)."Submitted (JUN-2006) to the PDB data bank
  13. "The structural basis of integrin-linked kinase-PINCH interactions."Proc. Natl. Acad. Sci. U.S.A. 105:20677-20682(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase."J. Biol. Chem. 284:5836-5844(2009) [PubMed] [Europe PMC] [Abstract]