≡

Autophagy Related Protein 16 Like Protein 1 (ATG16L1)

[Edit]

WDR30

Autophagy Related Protein 16 Like Protein 1 (ATG16L1)
CCC N942
HGNC 21498
MGI 1924290
PubMed 23973919
RGD 1310631
UniProt Q676U5
Wiki ATG16L1
Autophagy is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy.
The deduced 607-amino acid protein has a calculated molecular mass of 68.2 kD and shares 90% identity with one of the mouse Atg16l1 isoforms. All 4 ATG16L1 isoforms have an N-terminal coiled-coil domain, and the 3 longest isoforms have 7 C-terminal WD repeats. The shortest isoform has only 3 C-terminal WD repeats.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN942Hu01 Recombinant Autophagy Related Protein 16 Like Protein 1 (ATG16L1) Positive Control; Immunogen; SDS-PAGE; WB.
RPN942Hu02 Recombinant Autophagy Related Protein 16 Like Protein 1 (ATG16L1) Positive Control; Immunogen; SDS-PAGE; WB.
RPN942Hu03 Recombinant Autophagy Related Protein 16 Like Protein 1 (ATG16L1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAN942Hu01 Polyclonal Antibody to Autophagy Related Protein 16 Like Protein 1 (ATG16L1) WB; IHC; ICC; IP.
MAN942Hu21 Monoclonal Antibody to Autophagy Related Protein 16 Like Protein 1 (ATG16L1) WB; IHC; ICC; IP.
PAN942Hu02 Polyclonal Antibody to Autophagy Related Protein 16 Like Protein 1 (ATG16L1) WB; IHC; ICC; IP.
Assay Kits SEN942Hu ELISA Kit for Autophagy Related Protein 16 Like Protein 1 (ATG16L1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Autophagy Related Protein 16 Like Protein 1 (ATG16L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Autophagy Related Protein 16 Like Protein 1 (ATG16L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Autophagy Related Protein 16 Like Protein 1 (ATG16L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Autophagy Related Protein 16 Like Protein 1 (ATG16L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autophagy Related Protein 16 Like Protein 1 (ATG16L1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Autophagy Related Protein 16 Like Protein 1 (ATG16L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Autophagy Related Protein 16 Like Protein 1 (ATG16L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Autophagy Related Protein 16 Like Protein 1 (ATG16L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Autophagy Related Protein 16 Like Protein 1 (ATG16L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autophagy Related Protein 16 Like Protein 1 (ATG16L1) ELISA Kit Customized Service Offer
  1. "Cloning and analysis of human Apg16L."DNA Seq. 15:303-305(2004) [PubMed] [Europe PMC] [Abstract]
  2. "A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1." Nat. Genet. 39:207-211(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3."EMBO J. 32:566-582(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis." Nat. Genet. 39:596-604(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3."Nature 506:456-462(2014) [PubMed] [Europe PMC] [Abstract]
  13. "WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1."Mol. Cell 55:238-252(2014) [PubMed] [Europe PMC] [Abstract]