Signal Peptide Peptidase Like 2A (SPPL2A)

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IMP3; PSL2; Intramembrane protease 3; Presenilin-like protein 2

Signal Peptide Peptidase Like 2A (SPPL2A)
SPPL2A is a member of the signal peptide peptidase-like protease (SPPL) family and encodes an endosomal membrane protein with a protease associated (PA) domain. This protein plays a role in innate and adaptive immunity. A pseudogene of this gene also lies on chromosome 15.By searching sequence databases for homologs of Dictyostelium discoideum Impas, which shares homology with presenilin, followed by PCR of lymphocyte and hippocampus cDNA libraries, Grigorenko et al. (2002) cloned IMP3. The deduced protein contains 520 amino acids. Like other IMP proteins, IMP3 contains an N-terminal protease-associated (PA) domain, several transmembrane regions, a hydrophilic loop, conservative sequences around the first and second aspartate residues, and an invariant PAL motif near the C terminus.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Peptide Peptidase Like 2A (SPPL2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Peptide Peptidase Like 2A (SPPL2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Peptide Peptidase Like 2A (SPPL2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Peptide Peptidase Like 2A (SPPL2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Peptide Peptidase Like 2A (SPPL2A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Peptide Peptidase Like 2A (SPPL2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Peptide Peptidase Like 2A (SPPL2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Peptide Peptidase Like 2A (SPPL2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Peptide Peptidase Like 2A (SPPL2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Peptide Peptidase Like 2A (SPPL2A) ELISA Kit Customized Service Offer
  1. "Novel class of polytopic proteins with domains associated with putative protease activity."Biochemistry (Mosc.) 67:826-834(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of signal peptide peptidase, a presenilin-type aspartic protease."Science 296:2215-2218(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins."J. Biol. Chem. 279:50790-50798(2004) [PubMed] [Europe PMC] [Abstract]
  7. "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production."Nat. Cell Biol. 8:843-848(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b."Nat. Cell Biol. 8:894-896(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells."Cell Death Differ. 14:1678-1687(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b."J. Biol. Chem. 283:1644-1652(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]