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Salt Inducible Kinase 2 (SIK2)

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LOH11CR1I; QIK; SNF1LK2; SNF1-Like Kinase 2; Qin-induced kinase; Serine/threonine-protein kinase SNF1-like kinase 2

Salt Inducible Kinase 2 (SIK2)
CCC M257
HGNC 21680
MGI 2445031
PubMed 20708153
UniProt Q9H0K1
Wiki SNF1LK2
The SIK2 transcript contains 2 repetitive elements in the 3-prime UTR. RT-PCR ELISA detected moderate to high expression in all tissues examined. Highest expression was in kidney, followed in order by brain, ovary, heart, lung, skeletal muscle, pancreas, testis, and spleen. Sik2 contains an N-terminal serine/threonine protein kinase domain, a central domain with a ubiquitin-associate motif, and a C-terminal protein kinase A phosphorylation site. Northern blot analysis of several mouse tissues detected transcripts of 4.0 and 6.0 kb. Highest expression was in white adipose and brown adipose tissues. Testis showed intermediate Sik2 expression, and much lower expression was found in all other tissues examined. Fluorescence-labeled Sik2 was expressed mostly in the cytoplasm of transfected mouse preadipocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM257Hu01 Recombinant Salt Inducible Kinase 2 (SIK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM257Hu01 Polyclonal Antibody to Salt Inducible Kinase 2 (SIK2) WB; IHC; ICC; IP.
Assay Kits SEM257Hu ELISA Kit for Salt Inducible Kinase 2 (SIK2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM257Mu01 Recombinant Salt Inducible Kinase 2 (SIK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM257Mu01 Polyclonal Antibody to Salt Inducible Kinase 2 (SIK2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Salt Inducible Kinase 2 (SIK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Salt Inducible Kinase 2 (SIK2) ELISA Kit Customized Service Offer
  1. "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract].
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Testis.
  7. "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector."Cell 119:61-74(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy."J. Biol. Chem. 288:6227-6237(2013) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]