B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2)

[Edit]

BCL-W; BCLW; PPP1R51; Apoptosis regulator Bcl-W; Bcl-2-like protein 2

B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2)

Bcl2L2 encodes a pro-survival (anti-apoptotic) member of the bcl-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.

Relative to its Bcl-2 counterparts there is considerably less data on this particular protein however much effort is being made to further understand its cellular roles.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL251Hu01 Recombinant B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL251Hu01 Polyclonal Antibody to B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) WB; IHC; ICC; IP.
LAL251Hu81 FITC-Linked Polyclonal Antibody to B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) WB; IHC; ICC; IF.
LAL251Hu71 Biotin-Linked Polyclonal Antibody to B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL251Mu01 Recombinant B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL251Mu01 Polyclonal Antibody to B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL251Ra01 Recombinant B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL251Ra21 Monoclonal Antibody to B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) WB; IHC; ICC; IP.
PAL251Ra01 Polyclonal Antibody to B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) WB; IHC; ICC; IP.
Assay Kits SEL251Ra ELISA Kit for B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL251Ca01 Recombinant B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL251Ca01 Polyclonal Antibody to B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) ELISA Kit Customized Service Offer
  1. "Bcl-w, a novel member of the Bcl-2 family, promotes cell survival."Oncogene 13:665-675(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Tissue expression and subcellular localization of the pro-survival molecule Bcl-w."Cell Death Differ. 8:486-494(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity."J. Cell Biol. 162:877-887(2003) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity."EMBO J. 22:1497-1507(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix."J. Biol. Chem. 278:21124-21128(2003) [PubMed] [Europe PMC] [Abstract]