Methylmalonic Aciduria Type B Protein (MMAB)

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ATR; cblB; ATP:Cob(I)alamin Adenosyltransferase; Cobalamin Deficiency Type B

Methylmalonic Aciduria Type B Protein (MMAB)
MMAB encodes a protein that catalyzes the final step in the conversion of vitamin B12 into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group.The deduced 250-amino acid protein has a calculated molecular mass of 27.3 kD. MMAB shares 88% sequence identity with mouse Mmu. MMAB gene consists of 9 exons extending over 18.87 kb. Exon 9 ends at 2 alternative polyadenylation sites, and the intron-exon junctions are conserved between man and mouse. MMAB has a predicted leader sequence and signal cleavage site consistent with localization to the mitochondria.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methylmalonic Aciduria Type B Protein (MMAB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methylmalonic Aciduria Type B Protein (MMAB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methylmalonic Aciduria Type B Protein (MMAB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methylmalonic Aciduria Type B Protein (MMAB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methylmalonic Aciduria Type B Protein (MMAB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methylmalonic Aciduria Type B Protein (MMAB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methylmalonic Aciduria Type B Protein (MMAB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methylmalonic Aciduria Type B Protein (MMAB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methylmalonic Aciduria Type B Protein (MMAB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methylmalonic Aciduria Type B Protein (MMAB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methylmalonic Aciduria Type B Protein (MMAB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methylmalonic Aciduria Type B Protein (MMAB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methylmalonic Aciduria Type B Protein (MMAB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methylmalonic Aciduria Type B Protein (MMAB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methylmalonic Aciduria Type B Protein (MMAB) ELISA Kit Customized Service Offer
  1. "Identification of the gene responsible for the cblB complementation group of vitamin B(12)-dependent methylmalonic aciduria."Hum. Mol. Genet. 11:3361-3369(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of the human and bovine ATP:Cob(I)alamin adenosyltransferase cDNAs based on complementation of a bacterial mutant."J. Biol. Chem. 278:9227-9234(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  6. "Structure of ATP-bound human ATP:cobalamin adenosyltransferase."Biochemistry 45:15188-15196(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Genetic analysis of three genes causing isolated methylmalonic acidemia: identification of 21 novel allelic variants."Mol. Genet. Metab. 84:317-325(2005) [PubMed] [Europe PMC] [Abstract]