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Phosphoinositide-3-Kinase Class 3 (PIK3C3)

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Vps34; Phosphatidylinositol 3-kinase p100 subunit; Phosphatidylinositol 3-kinase catalytic subunit type 3

Phosphoinositide-3-Kinase Class 3 (PIK3C3)
CCC J828
HGNC 8974
MGI 2445019
PubMed 21283715
RGD 620899
UniProt Q8NEB9
Wiki PIK3C3
Phosphoinositide (PI) 3-kinases are involved in both receptor-mediated signal transduction and intracellular trafficking. In yeast, the vps34 gene product is a PI 3-kinase that mediates the active diversion of proteins from the secretory pathway to vacuoles. Mammals appear to have a family of PI 3-kinases, which also includes PIK3CG and PIK3CA. The full-length PIK3C3 cDNA encodes an 887-amino acid polypeptide that is 37% identical to yeast vps34 over its entire length. Its predicted and observed molecular mass is approximately 100 kD. PIK3C3 gene was expressed as a 3.7-kb transcript in all human tissues examined.The PIK3C3 gene does not associate with the p85 regulatory subunit but does form a complex with p150, a mammalian homolog of another protein in the yeast vps pathway.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ828Hu01 Recombinant Phosphoinositide-3-Kinase Class 3 (PIK3C3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ828Hu01 Polyclonal Antibody to Phosphoinositide-3-Kinase Class 3 (PIK3C3) WB; IHC; ICC; IP.
Assay Kits SEJ828Hu ELISA Kit for Phosphoinositide-3-Kinase Class 3 (PIK3C3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Class 3 (PIK3C3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Class 3 (PIK3C3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Class 3 (PIK3C3) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ828Mu ELISA Kit for Phosphoinositide-3-Kinase Class 3 (PIK3C3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Class 3 (PIK3C3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Class 3 (PIK3C3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Class 3 (PIK3C3) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ828Ra ELISA Kit for Phosphoinositide-3-Kinase Class 3 (PIK3C3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system."EMBO J. 14:3339-3348(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human VPS34 and p150 are Rab7 interacting partners."Traffic 4:754-771(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase."Proc. Natl. Acad. Sci. U.S.A. 105:19211-19216(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages."Nat. Cell Biol. 11:385-396(2009) [PubMed] [Europe PMC] [Abstract]
  8. "PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody."Nat. Cell Biol. 12:362-371(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."Cell 154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy."Mol. Cell. Biol. 33:3675-3688(2013) [PubMed] [Europe PMC] [Abstract]