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DNA Methyltransferase 1 (DNMT1)

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CXXC9; DNMT; MCMT; Cytosine-5 DNA Methyltransferase 1; CXXC-type zinc finger protein 9; DNA methyltransferase HsaI

DNA Methyltransferase 1 (DNMT1)
CCC J244
HGNC 2976
MGI 94912
PubMed 21745816
RGD 620979
UniProt P26358
Wiki DNMT1
DNA (cytosine-5)-methyltransferases (DNMTs), such as DNMT1, maintain patterns of methylated cytosine residues in the mammalian genome. Genomic methylation patterns are reshaped during gametogenesis and early development and undergo programmed alterations during cellular differentiation. Methylation patterns are responsible for the repression of parasitic sequence elements and the expression status of genes subject to genomic imprinting and X inactivation. Faithful maintenance of methylation patterns is required for normal mammalian development, and aberrant methylation patterns are associated with certain human tumors and developmental abnormalities.A DNMT1 enzyme is thought to be responsible for most of the maintenance as well as the de novo methylation activities occurring in the somatic cells of vertebrates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ244Hu01 Recombinant DNA Methyltransferase 1 (DNMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ244Hu01 Polyclonal Antibody to DNA Methyltransferase 1 (DNMT1) WB; IHC; ICC; IP.
MAJ244Hu21 Monoclonal Antibody to DNA Methyltransferase 1 (DNMT1) WB; IHC; ICC; IP.
Assay Kits SEJ244Hu ELISA Kit for DNA Methyltransferase 1 (DNMT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ244Mu01 Recombinant DNA Methyltransferase 1 (DNMT1) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ244Mu02 Recombinant DNA Methyltransferase 1 (DNMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ244Mu01 Polyclonal Antibody to DNA Methyltransferase 1 (DNMT1) WB; IHC; ICC; IP.
PAJ244Mu02 Polyclonal Antibody to DNA Methyltransferase 1 (DNMT1) WB; IHC; ICC; IP.
Assay Kits SEJ244Mu ELISA Kit for DNA Methyltransferase 1 (DNMT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Methyltransferase 1 (DNMT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Methyltransferase 1 (DNMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Methyltransferase 1 (DNMT1) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ244Ra ELISA Kit for DNA Methyltransferase 1 (DNMT1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  30. "SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities."Mol. Cell. Biol. 31:4720-4734(2011) [PubMed] [Europe PMC] [Abstract]
  31. "A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability."Nat. Struct. Mol. Biol. 18:42-48(2011) [PubMed] [Europe PMC] [Abstract]
  32. "The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1."Nucleic Acids Res. 39:8355-8365(2011) [PubMed] [Europe PMC] [Abstract]
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