Renal Fibrosis (RF)

Renal fibrosis, characterized by tubulointerstitial fibrosis and glomerulosclerosis, is the final manifestation of chronic kidney disease. Renal fibrosis is characterized by an excessive accumulation and deposition of extracellular matrix components. This pathologic result usually originates from both underlying complicated cellular activities such as epithelial-to-mesenchymal transition, fibroblast activation, monocyte/macrophage infiltration, and cellular apoptosis and the activation of signaling molecules such as transforming growth factor beta and angiotensin II.

Experimental models for renal fibrosis have identified a number of factors that contribute to renal scarring, particularly derangements of physiology involved in the autoregulation of glomerular filtration. This in turn leads to replacement of normal structures with accumulated extracellular matrix.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Models DSI519Mu01 Mouse Model for Renal Fibrosis (RF) Disease Model
DSI519Mu02 Mouse Model for Renal Fibrosis (RF) n/a
DSI519Mu03 Mouse Model for Renal Fibrosis (RF) n/a
Tissues n/a Tissue of Renal Fibrosis (RF) (If Necessary) Tissue Customized Service Offer
Serums n/a Serums of Renal Fibrosis (RF) (If Necessary) Serums Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Models DSI519Ra01 Rat Model for Renal Fibrosis (RF) Disease Model
DSI519Ra02 Rat Model for Renal Fibrosis (RF) n/a
DSI519Ra03 Rat Model for Renal Fibrosis (RF) n/a
Tissues n/a Tissue of Renal Fibrosis (RF) (If Necessary) Tissue Customized Service Offer
Serums n/a Serums of Renal Fibrosis (RF) (If Necessary) Serums Customized Service Offer

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Models DSI519Gu01 Cavia Model for Renal Fibrosis (RF) n/a
DSI519Gu02 Cavia Model for Renal Fibrosis (RF) n/a
DSI519Gu03 Cavia Model for Renal Fibrosis (RF) n/a
Tissues n/a Tissue of Renal Fibrosis (RF) (If Necessary) Tissue Customized Service Offer
Serums n/a Serums of Renal Fibrosis (RF) (If Necessary) Serums Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Models n/a Model for Renal Fibrosis (RF) Disease Model Customized Service Offer
Tissues n/a Tissue of Renal Fibrosis (RF) (If Necessary) Tissue Customized Service Offer
Serums n/a Serums of Renal Fibrosis (RF) (If Necessary) Serums Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Models n/a Model for Renal Fibrosis (RF) Disease Model Customized Service Offer
Tissues n/a Tissue of Renal Fibrosis (RF) (If Necessary) Tissue Customized Service Offer
Serums n/a Serums of Renal Fibrosis (RF) (If Necessary) Serums Customized Service Offer