Hair Dermal Papilla Cells (HDPC)

The dermal papillae are small, nipple-like extensions of the dermis into the epidermis. At the surface of the skin in hands and feet, they appear as epidermal or papillary ridges. They are a highly active group of cells derived from the dermis mesenchyme. The dermal papillae play a crucial role in hair growth cycle by inducing follicle development from the epidermis to produce hair fiber. 

Hair Dermal Papilla Cells (HDPC) are isolated from scalp tissue. A previous study showed that dermal papilla cells gradually lost their hair inductivity and proliferation capacity in long-term cultures. Hair follicle cycle can be induced directly or indirectly by the interaction between dermal papilla cells and the surrounding epithelial cells. To study the characteristics of hair papilla cells and their biological functions, it is of great significance to understand the development and regeneration of hair follicles.