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Leucyl/Cystinyl Aminopeptidase (LNPEP)

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CAP; PLAP; OTASE; IRAP; Oxytocinase; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; Placental leucine aminopeptidase

Leucyl/Cystinyl Aminopeptidase (LNPEP)
CCC H723
HGNC 6656
MGI 2387123
PubMed 21330387
RGD 621752
UniProt Q9UIQ6
Wiki LNPEP
LNPEP encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.
The deduced 944-amino acid polypeptide contains the HEXXH consensus sequence of zinc metallopeptidases as well as an N-terminal hydrophobic region that resembles a transmembrane domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH723Hu01 Recombinant Leucyl/Cystinyl Aminopeptidase (LNPEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH723Hu01 Polyclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IP.
MAH723Hu21 Monoclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IP.
Assay Kits SEH723Hu ELISA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) Enzyme-linked immunosorbent assay for Antigen Detection.
HEH723Hu High Sensitive ELISA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucyl/Cystinyl Aminopeptidase (LNPEP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucyl/Cystinyl Aminopeptidase (LNPEP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) ELISA Kit Customized Service Offer
  1. "Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family."J. Biol. Chem. 271:56-61(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The complete amino acid sequence of human placental oxytocinase."Biochim. Biophys. Acta 1352:1-7(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21."Eur. J. Biochem. 267:2297-2306(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides."Eur. J. Biochem. 268:3259-3266(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules."Immunogenetics 39:230-242(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of human placental leucine aminopeptidase as oxytocinase."Arch. Biochem. Biophys. 292:388-392(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase."J. Biol. Chem. 276:48623-48626(2001) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]