Tumor Protein p53 Binding Protein 1 (TP53BP1)

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53BP1; p53BP1; p202

Tumor Protein p53 Binding Protein 1 (TP53BP1)
TP53BP1 has a predicted molecular mass of 217 kD and shows homology in its C-terminal 247 amino acids to the C terminus of the tumor suppressor protein BRCA1. TP53BP1 was present in both the cytoplasm and nucleus in some cells and only in the nucleus in others. Furthermore, there were 2 nuclear staining patterns, one homogeneous staining and the other dot staining.TP53BP1 was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation. TP53BP1 played a partially redundant role in phosphorylation of the downstream checkpoint effector proteins BRCA1 and CHK2 but was required for the formation of BRCA1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH009Hu01 Recombinant Tumor Protein p53 Binding Protein 1 (TP53BP1) Positive Control; Immunogen; SDS-PAGE; WB.
MPH009Hu01 Phosphorylated Tumor Protein p53 Binding Protein 1 (TP53BP1) n/a
Antibodies MAH009Hu21 Monoclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) WB; IHC; ICC; IP.
PAH009Hu01 Polyclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) WB; IHC; ICC; IP.
AAH009Hu01 Anti-Phosphorylated Tumor Protein p53 Binding Protein 1 (TP53BP1) Polyclonal Antibody WB.
AAH009Hu02 Anti-Phosphorylated Tumor Protein p53 Binding Protein 1 (TP53BP1) Monoclonal Antibody WB.
Assay Kits SEH009Hu ELISA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Protein p53 Binding Protein 1 (TP53BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Protein p53 Binding Protein 1 (TP53BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) ELISA Kit Customized Service Offer
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