Secretagogin (SCGN)

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SECRET; SEGN; CALBL; Calbindin-Like; Secretagogin,EF-Hand Calcium Binding Protein

Secretagogin (SCGN)
SCGN contains 6 tandem repeats of the EF-hand Ca(2+)-binding domain, with a loop at all 6 putative Ca(2+)-binding sites, and shares significant similarity with calbindin and calretinin. Much lower expression of only the smaller transcript was detected in adrenal medulla, stomach, thyroid, colon, and small intestine.
Immunohistochemical analysis showed SCGN expression restricted to the islet of Langerhans in pancreas, in C cells near thyroid follicles, and at sites typically occupied by neuroendocrine cells in all other tissues examined. Cell fractionation and confocal imaging of transfected rat insulinoma cells detected Scgn predominantly in the cytosolic fraction, with much less Scgn in nuclei. SCGN was expressed in a reticular pattern in transfected COS cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG850Hu01 Recombinant Secretagogin (SCGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG850Hu01 Polyclonal Antibody to Secretagogin (SCGN) WB; IHC; ICC; IP.
MAG850Hu21 Monoclonal Antibody to Secretagogin (SCGN) WB; IHC; ICC; IP.
Assay Kits SEG850Hu ELISA Kit for Secretagogin (SCGN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG850Mu01 Recombinant Secretagogin (SCGN) Positive Control; Immunogen; SDS-PAGE; WB.
RPG850Mu02 Recombinant Secretagogin (SCGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG850Mu01 Polyclonal Antibody to Secretagogin (SCGN) WB; IHC; ICC; IP.
PAG850Mu02 Polyclonal Antibody to Secretagogin (SCGN) WB; IHC; ICC; IP.
Assay Kits SEG850Mu ELISA Kit for Secretagogin (SCGN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG850Ra01 Recombinant Secretagogin (SCGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG850Ra01 Polyclonal Antibody to Secretagogin (SCGN) WB; IHC; ICC; IP.
MAG850Ra21 Monoclonal Antibody to Secretagogin (SCGN) WB; IHC; ICC; IP.
Assay Kits CEG850Ra ELISA Kit for Secretagogin (SCGN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein."J. Biol. Chem. 275:24740-24751(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein."Cereb. Cortex 11:1161-1169(2001) [PubMed] [Europe PMC] [Abstract]