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Methionine Adenosyltransferase II Beta (MAT2b)

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MATIIbeta; TGR; SDR23E1; Short Chain Dehydrogenase/Reductase Family 23E,Member 1; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase

Methionine Adenosyltransferase II Beta (MAT2b)
CCC G468
HGNC 6905
MGI 1913667
PubMed 11337507
RGD 1593534
UniProt Q9NZL9
Methionine adenosyltransferase (MAT; EC 2.5.1.6) catalyzes the biosynthesis of S-adenosylmethionine (AdoMet) from methionine and ATP. MAT II is a broadly expressed MAT consisting of catalytic alpha and noncatalytic beta subunits encoded by MAT2A) and MAT2B, respectively.
LeGros et al. (2000) designed degenerate PCR primers to tryptic peptide sequence of MAT2B purified from human lymphocytes. They amplified a partial cDNA from Jurkat cells and extended the cDNA using 3-prime and 5-prime RACE. A full-length MAT2B cDNA amplified from normal human peripheral blood mononuclear cell RNA encodes a 334-amino acid protein with a molecular mass of 38 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG468Hu01 Recombinant Methionine Adenosyltransferase II Beta (MAT2b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Methionine Adenosyltransferase II Beta (MAT2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methionine Adenosyltransferase II Beta (MAT2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methionine Adenosyltransferase II Beta (MAT2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionine Adenosyltransferase II Beta (MAT2b) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methionine Adenosyltransferase II Beta (MAT2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methionine Adenosyltransferase II Beta (MAT2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methionine Adenosyltransferase II Beta (MAT2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methionine Adenosyltransferase II Beta (MAT2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionine Adenosyltransferase II Beta (MAT2b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methionine Adenosyltransferase II Beta (MAT2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methionine Adenosyltransferase II Beta (MAT2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methionine Adenosyltransferase II Beta (MAT2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methionine Adenosyltransferase II Beta (MAT2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionine Adenosyltransferase II Beta (MAT2b) ELISA Kit Customized Service Offer
  1. "Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II)."J. Biol. Chem. 275:2359-2366(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of the human MAT2B gene encoding the regulatory beta subunit of methionine adenosyltransferase, MAT II."J. Biol. Chem. 276:24918-24924(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma."Gastroenterology 124:940-948(2003) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]